Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination.
Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination.
复制标题
DOI：
10.1002/ijc.30043
复制
发表时间：
2016-08-01
影响因子：
6.4
通讯作者：
Samant, Rajeev S.
中科院分区：
文献类型：
--
作者：
Pruitt, Hawley C.;Devine, Daniel J.;Samant, Rajeev S.
N-myc & STAT Interactor，NMI是一种蛋白质，主要研究其与转录因子的物理相互作用，这些转录因子在肿瘤生长，进展和转移中起关键作用。NMI是一种可诱导的蛋白质，因此其细胞内水平和位置可以显著变化，以依赖于环境的方式影响多种细胞功能。NMI与其结合伴侣的物理相互作用与肿瘤生物学的许多方面有关，包括DNA损伤反应，细胞死亡，上皮向间质转化和干细胞。因此，发现更多关于NMI功能的细节可以揭示c-Myc，STAT和BRCA 1等转录因子如何受到上下文调控的关键见解。虽然尚未发现NMI的正常生理功能，但它在从病毒感染到癌症的病理学中具有潜在作用。这篇综述及时地探讨了NMI的作用，特别关注癌症进展和转移。
N‐myc & STAT Interactor, NMI, is a protein that has mostly been studied for its physical interactions with transcription factors that play critical roles in tumor growth, progression and metastasis. NMI is an inducible protein, thus its intracellular levels and location can vary dramatically, influencing a diverse array of cellular functions in a context‐dependent manner. The physical interactions of NMI with its binding partners have been linked to many aspects of tumor biology including DNA damage response, cell death, epithelial‐to‐mesenchymal transition and stemness. Thus, discovering more details about the function(s) of NMI could reveal key insights into how transcription factors like c‐Myc, STATs and BRCA1 are contextually regulated. Although a normal, physiological function of NMI has not yet been discovered, it has potential roles in pathologies ranging from viral infection to cancer. This review provides a timely perspective of the unfolding roles of NMI with specific focus on cancer progression and metastasis.
登录
查看更多内容
影响因子：
3.5
作者：
Jung, HH;Lee, J;Im, YH
通讯作者：
Im, YH
影响因子：
56.9
作者：
Chin, YE;Kitagawa, M;Fu, XY
通讯作者：
Fu, XY
影响因子：
3.3
作者：
Jung, Chang Hwa;Jun, Chang Bong;Kim, Do-Hyung
通讯作者：
Kim, Do-Hyung
影响因子：
8
作者：
Bannasch, D;Weis, I;Schwab, M
通讯作者：
Schwab, M
影响因子：
3.3
作者：
Hosokawa, Nao;Hara, Taichi;Mizushima, Noboru
通讯作者：
Mizushima, Noboru