Opioid agonist and antagonist use and the gut microbiota: associations among people in addiction treatment.
Opioid agonist and antagonist use and the gut microbiota: associations among people in addiction treatment.
复制标题
阿片类药物和拮抗剂的使用以及肠道菌群：成瘾治疗中的人们之间的关联。
DOI：
10.1038/s41598-020-76570-9
复制
发表时间：
2020-11-10
影响因子：
4.6
通讯作者：
Foxman B
中科院分区：
文献类型：
--
作者：
Gicquelais RE;Bohnert ASB;Thomas L;Foxman B
小鼠模型表明，阿片类药物改变肠道微生物群，这可能影响阿片类药物耐受性和精神病理学。我们研究了肠道微生物群特征如何与接受门诊成瘾治疗的人中阿片类激动剂和拮抗剂的使用相关。患者（n = 46）采集粪便样本，并按入组前一个月内使用阿片类激动剂（海洛因、处方阿片类药物）、拮抗剂（纳洛酮）、激动剂-拮抗剂组合（丁丙诺啡-纳洛酮）或既不使用激动剂也不使用拮抗剂进行分组。我们使用Illumina MiSeq对16 S rRNA基因的V4区域进行测序，以检查α多样性，肠型和细菌属的相对丰度如何因阿片类激动剂和拮抗剂暴露而变化。与31名既不使用激动剂也不使用拮抗剂的参与者相比，5名使用阿片类激动剂（无拮抗剂）的参与者具有较低的微生物群多样性，拟杆菌肠型，以及较低的罗斯拜瑞氏菌属（一种丁酸盐生产属）和嗜胆汁酸菌属（一种胆汁酸代谢属）的相对丰度。在使用激动剂+拮抗剂（n = 4）、仅使用拮抗剂（n = 6）以及既不使用激动剂也不使用拮抗剂的那些之间，肠道微生物群特征没有差异。与小鼠吗啡暴露模型类似，阿片类激动剂的使用与较低的微生物群多样性相关。罗斯拜瑞氏菌属和嗜胆菌属丰度较低可能与阿片类药物暴露小鼠中观察到的肠道炎症/渗透性和胆汁酸代谢失调有关。
Murine models suggest that opioids alter the gut microbiota, which may impact opioid tolerance and psychopathology. We examined how gut microbiota characteristics related to use of opioid agonists and antagonists among people receiving outpatient addiction treatment. Patients (n = 46) collected stool samples and were grouped by use of opioid agonists (heroin, prescription opioids), antagonists (naltrexone), agonist–antagonist combinations (buprenorphine–naloxone), or neither agonists nor antagonists within the month before enrollment. We sequenced the V4 region of the 16S rRNA gene using Illumina MiSeq to examine how alpha diversity, enterotypes, and relative abundance of bacterial genera varied by opioid agonist and antagonist exposures. Compared to 31 participants who used neither agonists nor antagonists, 5 participants who used opioid agonists (without antagonists) had lower microbiota diversity, Bacteroides enterotypes, and lower relative abundance of Roseburia, a butyrate producing genus, and Bilophila, a bile acid metabolizing genus. There were no differences in gut microbiota features between those using agonist + antagonists (n = 4), antagonists only (n = 6), and neither agonists nor antagonists. Similar to murine morphine exposure models, opioid agonist use was associated with lower microbiota diversity. Lower abundance of Roseburia and Bilophila may relate to the gut inflammation/permeability and dysregulated bile acid metabolism observed in opioid-exposed mice.
登录
查看更多内容
影响因子：
5.6
作者：
Fu BC;Randolph TW;Lim U;Monroe KR;Cheng I;Wilkens LR;Le Marchand L;Hullar MA;Lampe JW
通讯作者：
Lampe JW
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
1.8
作者：
Feigelson, Heather Spencer;Bischoff, Kimberly;Goedert, James J
通讯作者：
Goedert, James J
影响因子：
3.7
作者：
Barengolts E;Green SJ;Eisenberg Y;Akbar A;Reddivari B;Layden BT;Dugas L;Chlipala G
通讯作者：
Chlipala G
影响因子：
4.4
作者：
Kozich, James J.;Westcott, Sarah L.;Schloss, Patrick D.
通讯作者：
Schloss, Patrick D.