Carbon dioxide provocation of anxiety and respiratory response in bipolar disorder.
Carbon dioxide provocation of anxiety and respiratory response in bipolar disorder.
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二氧化碳引发躁郁症患者的焦虑和呼吸反应。
DOI：
10.1016/j.jad.2006.08.029
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发表时间：
2007
影响因子：
6.6
通讯作者：
Hoehn-Saric,Rudolf
中科院分区：
文献类型：
--
作者：
MacKinnon,DeanF;Craighead,Brandie;Hoehn-Saric,Rudolf
背景频繁的双相/惊恐共病意味着双相患者可能经历CO2引起的焦虑和呼吸模式的变化，这些变化与惊恐障碍患者的经历相似。呼吸和主观焦虑的措施进行了收集。呼吸CO2的受试者更焦虑，呼吸更深，更快，比空气中的焦虑程度增加归因于CO2的增加程度与分钟通气量的增加直接相关。五个人被评估为恐慌发作。恐慌反应CO2预测的焦虑程度与空气alone.CONCLUSIONSComparison与类似的恐慌研究的结果表明，双相情感障碍与增强呼吸反应CO2。双相情感障碍患者对二氧化碳的超敏反应表明，双相情感障碍和惊恐障碍可能存在共同的病理机制。这些初步数据支持CO2挑战在双相受试者中的扩展应用。
BACKGROUNDFrequent bipolar/panic comorbidity implies bipolar individuals may experience CO2-provoked anxiety and changes in respiratory patterns similar to those experienced by individuals with panic disorder.METHODS16 euthymic bipolar individuals breathed air and air combined with 5% CO2for 15 min each. Respiratory and subjective anxiety measures were collected.RESULTSOn CO2subjects were more anxious and breathed more deeply and rapidly than with air; the degree of increase in anxiety attributable to CO2was directly correlated with the degree of increase in minute ventilation. Five individuals were assessed as having a panic attack. Panic response to CO2was predicted by the degree of anxiety experienced with air alone.CONCLUSIONSComparison with the results of similar panic studies shows bipolar disorder is associated with enhanced respiratory response to CO2. Hypersensitivity to CO2among bipolar individuals suggests a possible pathological mechanism common to both bipolar and panic disorders. These preliminary data support the expanded application of CO2challenges in bipolar subjects.
响应％20至％20过度换气％20和％20吸入％20的％205.5％％20碳％20富含二氧化碳的％20空气％20跨％20％20DSM-III-R％20焦虑％20疾病。
影响因子：
4.6
作者：
Ronald M. Rapee;Timothy A. Brown;Martin M. Antony;David H. Barlow
通讯作者：
David H. Barlow
恐慌症的呼吸心理生理学：98 名受试者的三种呼吸挑战。
DOI：
10.1176/ajp.154.11.1557
发表时间：
1997
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Papp,LA;Martinez,JM;Klein,DF;Coplan,JD;Norman,RG;Cole,R;deJesus,MJ;Ross,D;Goetz,R;Gorman,JM
通讯作者：
Gorman,JM
躁郁症的恐慌共病：躁狂与恐慌有何联系？
影响因子：
5.4
作者：
D. MacKinnon;Rachel B. Zamoiski
通讯作者：
Rachel B. Zamoiski