Potential Neuroprotective Role of Melatonin in Sepsis-Associated Encephalopathy Due to Its Scavenging and Anti-Oxidative Properties.
Potential Neuroprotective Role of Melatonin in Sepsis-Associated Encephalopathy Due to Its Scavenging and Anti-Oxidative Properties.
复制标题
DOI：
10.3390/antiox12091786
复制
发表时间：
2023-09-21
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
脓毒症定义为由宿主对感染的反应失调引起的危及生命的器官功能障碍。脑是脓毒症涉及的器官之一，脓毒症诱导的脑损伤表现为脓毒症相关脑病（SAE）。高达70%的脓毒症患者可能存在SAE。SAE具有非常广泛的临床症状，从轻度行为变化到认知障碍到意识障碍和昏迷。SAE的存在增加了脓毒症患者人群的死亡率，并可能导致脓毒症幸存者的慢性认知功能障碍。因此，需要在脓毒症中具有神经保护作用的治疗干预。褪黑激素是一种负责控制昼夜节律的神经激素，具有许多有益的生理作用。它的抗炎和抗氧化特性被很好地描述。它被认为是脓毒症的潜在治疗因素，动物模型研究的结果是积极的，第一次人体临床试验的结果令人鼓舞。由于其抗氧化和抗炎潜力，它也可能在脓毒症相关脑病中发挥神经保护作用。该审查提出的数据褪黑激素作为一种潜在的药物在SAE的病理生理学SAE和松果体神经激素的具体行动的更广泛的背景下。
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The brain is one of the organs involved in sepsis, and sepsis-induced brain injury manifests as sepsis-associated encephalopathy (SAE). SAE may be present in up to 70% of septic patients. SAE has a very wide spectrum of clinical symptoms, ranging from mild behavioral changes through cognitive disorders to disorders of consciousness and coma. The presence of SAE increases mortality in the population of septic patients and may lead to chronic cognitive dysfunction in sepsis survivors. Therefore, therapeutic interventions with neuroprotective effects in sepsis are needed. Melatonin, a neurohormone responsible for the control of circadian rhythms, exerts many beneficial physiological effects. Its anti-inflammatory and antioxidant properties are well described. It is considered a potential therapeutic factor in sepsis, with positive results from studies on animal models and with encouraging results from the first human clinical trials. With its antioxidant and anti-inflammatory potential, it may also exert a neuroprotective effect in sepsis-associated encephalopathy. The review presents data on melatonin as a potential drug in SAE in the wider context of the pathophysiology of SAE and the specific actions of the pineal neurohormone.
登录
查看更多内容
褪黑素对 α 7nAchR 的调节通过抑制 HMGB1 介导的小胶质细胞激活和 CRTC1 介导的神经元丢失来减轻缺血和再灌注导致的血脑屏障完整性受损
影响因子：
4
作者：
Chen, Shuang;Sun, Yanyun;Jin, Xinchun
通讯作者：
Jin, Xinchun
影响因子：
--
作者：
Chang CC;Huang TY;Chen HY;Huang TC;Lin LC;Chang YJ;Hsia SM
通讯作者：
Hsia SM
影响因子：
7.3
作者：
Cecon, Erika;Oishi, Atsuro;Jockers, Ralf
通讯作者：
Jockers, Ralf
影响因子：
2.2
作者：
Erbas, Oytun;Taskiran, Dilek
通讯作者：
Taskiran, Dilek
DOI：
10.1007/7854_2022_363
发表时间：
2023-01-01
期刊：
MICROORGANISMS AND MENTAL HEALTH
影响因子：
--
作者：
Dantzer, Robert
通讯作者：
Dantzer, Robert