Peptide-functionalized NaGdF(4) nanoparticles for tumor-targeted magnetic resonance imaging and effective therapy.
Peptide-functionalized NaGdF(4) nanoparticles for tumor-targeted magnetic resonance imaging and effective therapy.
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用于肿瘤靶向磁共振成像和有效治疗的肽功能化NaGdF4纳米颗粒
作者：
Metallic nanoparticles showed potent efficacy for diagnosis and therapy of cancer, but their clinical applications are limited by their poor tumor-targeting ability. Herein, peptide-functionalized 9 nm NaGdF4 nanoparticles (termed as, NaGdF4@bp-peptide NPs) have been synthesized through the Gd–phosphate coordination reaction of the spherical NaGdF4 nanoparticles with phosphopeptides (sequence: KLAKLAKKLAKLAKG(p-S)GAKRGARSTA, p-S means phosphorylated serine) including a p32 protein binding motif incorporating a cell-penetrating function, and a proapoptotic domain. The NaGdF4@bp-peptide NPs are ready to be efficiently internalized by cancer cells; they show a much higher cytotoxicity in MCF-7 breast cancer cells than the casein phosphopeptide (CPP) modified NaGdF4 nanoparticles (termed as, NaGdF4@CPP NPs). Using mouse-bearing MCF-7 breast cancer as a model system, the in vivo experimental results demonstrate that NaGdF4@bp-peptide NPs have integration of T1-weighted magnetic resonance imaging (MRI) contrast and tumor-targeting functionalities, and are able to suppress tumor growth without causing systemic toxicity.
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影响因子：
18.2
作者：
Kim D;Kim J;Park YI;Lee N;Hyeon T
通讯作者：
Hyeon T
影响因子：
11.2
作者：
Fogal V;Zhang L;Krajewski S;Ruoslahti E
通讯作者：
Ruoslahti E
癌症抗血管生成治疗的当前挑战和纳米治疗的前景。
影响因子：
12.4
作者：
Abdalla AME;Xiao L;Ullah MW;Yu M;Ouyang C;Yang G
通讯作者：
Yang G
影响因子：
14
作者：
Fang, Jie;Chandrasekharan, Prashant;Ding, Jun
通讯作者：
Ding, Jun
影响因子：
38.3
作者：
通讯作者：
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