Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19.
Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19.
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DOI：
10.3390/jcm10173907
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发表时间：
2021-08-30
影响因子：
3.9
通讯作者：
Loosen SH
中科院分区：
文献类型：
--
作者：
Hayek SS;Roderburg C;Blakely P;Launius C;Eugen-Olsen J;Tacke F;Ktena S;Keitel V;Luedde M;Giamarellos-Bourboulis EJ;Luedde T;Loosen SH
背景：严重冠状病毒病2019(新冠肺炎)是对严重急性呼吸综合征冠状病毒2型的高炎症反应的结果。炎症的生物标志物已被用于新冠肺炎患者的危险分层。骨桥蛋白(OPN)是一种整合素结合的糖磷蛋白，参与调节白细胞的激活；其水平与脓毒症患者的不良预后有关。骨桥蛋白水平是否能预测新冠肺炎的预后尚不清楚。方法：对入院48h内收集的341例新冠肺炎患者的血清骨桥蛋白水平进行检测。我们描述了OPN水平的决定因素，并检查了它们与住院结果的关系；特别是死亡、是否需要机械通气、是否需要肾脏替代治疗(RRT)以及作为一个综合结果。比较OPN与其他炎性标志物的风险识别能力。结果：新冠肺炎患者(平均年龄60岁，男性61.9%，黑人27.0%)血清骨桥蛋白水平显著高于健康志愿者(96.63vs.16.56 ng/mL，p<；0.001)。总体而言，104名患者需要机械通气，35名患者需要透析，53名患者在住院期间死亡。在多变量分析中，≥水平为140.66 ng/m L(三分位数)与死亡几率增加3.5×(95%可信区间1.44~8.27)和需要机械通气几率增加4.9×(95%可信区间2.48~9.80)相关。OPN与RRT需求之间没有关联。最后，相对于复合终点，上三分位数的OPN水平被证明是无事件生存的独立预后因素。结论：较高的骨桥蛋白水平与新冠肺炎患者死亡和机械通气的风险增加相关，然而，它们在分诊中的有效性值得怀疑。
Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphoprotein involved in the modulation of leukocyte activation; its levels are associated with worse outcomes in patients with sepsis. Whether OPN levels predict outcomes in COVID-19 is unknown. Methods: We measured OPN levels in serum of 341 hospitalized COVID-19 patients collected within 48 h from admission. We characterized the determinants of OPN levels and examined their association with in-hospital outcomes; notably death, need for mechanical ventilation, and need for renal replacement therapy (RRT) and as a composite outcome. The risk discrimination ability of OPN was compared with other inflammatory biomarkers. Results: Patients with COVID-19 (mean age 60, 61.9% male, 27.0% blacks) had significantly higher levels of serum OPN compared to healthy volunteers (96.63 vs. 16.56 ng/mL, p < 0.001). Overall, 104 patients required mechanical ventilation, 35 needed dialysis, and 53 died during their hospitalization. In multivariable analyses, OPN levels ≥140.66 ng/mL (third tertile) were associated with a 3.5 × (95%CI 1.44–8.27) increase in the odds of death, and 4.9 × (95%CI 2.48–9.80) increase in the odds of requiring mechanical ventilation. There was no association between OPN and need for RRT. Finally, OPN levels in the upper tertile turned out as an independent prognostic factor of event-free survival with respect to the composite endpoint. Conclusion: Higher OPN levels are associated with increased odds of death and mechanical ventilation in patients with COVID-19, however, their utility in triage is questionable.
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影响因子：
13.6
作者：
Azam, Tariq U.;Shadid, Husam R.;Hayek, Salim S.
通讯作者：
Hayek, Salim S.
DOI：
10.1016/s2213-2600(21)00081-3
发表时间：
2021-05
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Soin AS;Kumar K;Choudhary NS;Sharma P;Mehta Y;Kataria S;Govil D;Deswal V;Chaudhry D;Singh PK;Gupta A;Agarwal V;Kumar S;Sangle SA;Chawla R;Narreddy S;Pandit R;Mishra V;Goel M;Ramanan AV
通讯作者：
Ramanan AV
影响因子：
2.6
作者：
Varım C;Demirci T;Cengiz H;Hacıbekiroğlu İ;Tuncer FB;Çokluk E;Toptan H;Karabay O;Yıldırım İ
通讯作者：
Yıldırım İ
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
6
作者：
Castello, Luigi Mario;Baldrighi, Marco;Chiocchetti, Annalisa
通讯作者：
Chiocchetti, Annalisa