Relationship between serum osteopontin levels and the severity of COVID-19 infection.
Relationship between serum osteopontin levels and the severity of COVID-19 infection.
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DOI：
10.1007/s00508-020-01789-5
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发表时间：
2021-04
影响因子：
2.6
通讯作者：
Yıldırım İ
中科院分区：
文献类型：
--
作者：
Varım C;Demirci T;Cengiz H;Hacıbekiroğlu İ;Tuncer FB;Çokluk E;Toptan H;Karabay O;Yıldırım İ
冠状病毒病2019(新冠肺炎)是一种急性炎症性呼吸道疾病。骨桥蛋白(OPN)是一种主要的糖蛋白，表达于多种细胞类型，如骨细胞、免疫细胞、平滑肌细胞、上皮细胞和内皮细胞。它也是免疫反应的主要调节器。本研究的目的是揭示血清骨桥蛋白水平在预测新冠肺炎患者病情严重程度中的地位。这项研究包括84名女性患者，其中女性43名，男性45名。患者分为2组，1组非重症组(n=48)，2组重度组(n=40)。记录人口学资料、中性粒细胞、淋巴细胞、血小板、白细胞计数、白蛋白、降钙素原、C反应蛋白(CRP)和骨桥蛋白水平。比较两组患者的骨桥蛋白水平及上述炎症指标。两组在性别(女/男25/23比18/22)和血小板计数(178 K/μL比191 K/μL)方面没有显著差异(p >； 0.05)。年龄(57.7 ± 17.0岁vs 71.4 ± 12.8岁)、降钙素原(0.07 vs 0.24 ng/mL)、C反应蛋白(17 vs 158 mg/L)、中性粒细胞计数(3.7vs 5.64 K/μL)、白细胞计数(5.38vs 7.85 K/μL)和死亡人数(0 Vs 26)(p <； 0.001)。骨桥蛋白水平(98.5vs13.75 ng/mL，p = 0.002)在两组间差异有统计学意义(p<0.05)。
Coronavirus disease 2019 (COVID-19) is an acute inflammatory respiratory disease. Osteopontin (OPN) is a glycoprotein expressed in various cell types, such as bone, immune, smooth muscle, epithelial and endothelial cells. It also acts as a regulator of immune response. The aim of the present study was to reveal the place of serum osteopontin levels in predicting severity among patients with COVID-19. This study included 84 patients, 43 female and 45 male. Patients were divided into 2 groups, group 1 non-severe group (n: 48), group 2 severe (n: 40). Demographic data, neutrophil, lymphocyte, platelet, white blood cell counts, albumin, procalcitonin, C‑reactive protein (CRP) and OPN levels were recorded. The OPN levels and these inflammatory parameters of the two groups were compared. There were no significant differences in terms of gender (female/male 25/23 vs. 18/22) and platelet count (178 K/μL vs. 191 K/μL) between the groups (p > 0.05). Ages (57.7 ± 17.0 years vs. 71.4 ± 12.8 years), procalcitonin (0.07 vs. 0.24 ng/mL), CRP (17 vs 158 mg/l), neutrophil count (3.7 vs 5.64 K/μL), WBC counts (5.38 vs 7.85 K/μL) and number of deaths (0 vs 26) (p < 0.001). The OPN levels (98.5 vs 13.75 ng/mL, p = 0.002) were found to be statistically higher, in group 2 than group 1. The present study showed that OPN can be used to predict the severity in patients with COVID-19.
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