Capsaicin cough sensitivity and the association with clinical parameters in bronchiectasis.
Capsaicin cough sensitivity and the association with clinical parameters in bronchiectasis.
复制标题
DOI：
10.1371/journal.pone.0113057
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhong NS
中科院分区：
文献类型：
--
作者：
Guan WJ;Gao YH;Xu G;Lin ZY;Tang Y;Li HM;Lin ZM;Zheng JP;Chen RC;Zhong NS
咳嗽过敏是呼吸道疾病中常见的一种。确定辣椒素咳嗽敏感性与临床稳定型支气管扩张成人临床参数之间的关系。我们招募了135名连续的成人支气管扩张症患者和22名健康受试者。进行病史询问、痰培养、肺功能测定、胸部高分辨率计算机断层扫描（HRCT）、莱斯特咳嗽问卷评分、支气管扩张严重程度指数（BSI）评估和辣椒素吸入激发。咳嗽敏感性被测量为引起至少2次（C2）和5次咳嗽（C5）的辣椒素浓度。支气管扩张组C2和C5均明显低于健康对照组（P<0.01），但两者有明显重叠。较低的C5水平与支气管扩张症状持续时间较长、HRCT评分较差、24小时痰量、BSI和痰脓性评分较高以及痰培养铜绿假单胞菌阳性相关。与辣椒素咳嗽敏感性增加相关的决定因素，定义为C5 ≤ 62.5 μmol/L，包括女性（OR：3.25，95%CI：1.35-7.83，P<0.01），HRCT总分在7-12之间（OR：2.57，95%CI：1.07-6.173，P = 0.04），BSI在5-8之间（OR：4.05，95%CI：1.48-11.06，P<0.01）和9或更高（OR：4.38，95%CI：1.48-12.93，P<0.01）。 支气管扩张症患者中辣椒素咳嗽敏感性增高，并与疾病严重程度相关。性别和疾病的严重程度，而不是痰脓，是辣椒素咳嗽敏感性增加的独立决定因素。由于与健康受试者重叠，目前用于咳嗽敏感性诊断的检测可能受到限制，但可能为未来临床试验中的咳嗽评估提供客观指标。
Cough hypersensitivity has been common among respiratory diseases. To determine associations of capsaicin cough sensitivity and clinical parameters in adults with clinically stable bronchiectasis. We recruited 135 consecutive adult bronchiectasis patients and 22 healthy subjects. History inquiry, sputum culture, spirometry, chest high-resolution computed tomography (HRCT), Leicester Cough Questionnaire scoring, Bronchiectasis Severity Index (BSI) assessment and capsaicin inhalation challenge were performed. Cough sensitivity was measured as the capsaicin concentration eliciting at least 2 (C2) and 5 coughs (C5). Despite significant overlap between healthy subjects and bronchiectasis patients, both C2 and C5 were significantly lower in the latter group (all P<0.01). Lower levels of C5 were associated with a longer duration of bronchiectasis symptoms, worse HRCT score, higher 24-hour sputum volume, BSI and sputum purulence score, and sputum culture positive for P. aeruginosa. Determinants associated with increased capsaicin cough sensitivity, defined as C5 being 62.5 µmol/L or less, encompassed female gender (OR: 3.25, 95%CI: 1.35–7.83, P<0.01), HRCT total score between 7–12 (OR: 2.57, 95%CI: 1.07–6.173, P = 0.04), BSI between 5–8 (OR: 4.05, 95%CI: 1.48–11.06, P<0.01) and 9 or greater (OR: 4.38, 95%CI: 1.48–12.93, P<0.01). Capsaicin cough sensitivity is heightened in a subgroup of bronchiectasis patients and associated with the disease severity. Gender and disease severity, but not sputum purulence, are independent determinants of heightened capsaicin cough sensitivity. Current testing for cough sensitivity diagnosis may be limited because of overlap with healthy subjects but might provide an objective index for assessment of cough in future clinical trials.
登录
查看更多内容
影响因子：
14.2
作者：
Hilton, Emma C. Y.;Baverel, Paul G.;Smith, Jaclyn A.
通讯作者：
Smith, Jaclyn A.
影响因子：
24.3
作者：
Murray, M. P.;Turnbull, K.;Hill, A. T.
通讯作者：
Hill, A. T.
影响因子：
4.8
作者：
Milross, Maree A;Piper, Amanda J;Bye, Peter T P
通讯作者：
Bye, Peter T P
DOI：
10.1164/rccm.201309-1575oc
发表时间：
2014-03-01
影响因子：
24.7
作者：
Chalmers, James D.;Goeminne, Pieter;Hill, Adam T.
通讯作者：
Hill, Adam T.
DOI：
10.1152/physiol.00026.2008
发表时间：
2008-12
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Bessac BF;Jordt SE
通讯作者：
Jordt SE