Engineering the Surface of Therapeutic "Living" Cells.
Engineering the Surface of Therapeutic "Living" Cells.
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DOI：
10.1021/acs.chemrev.7b00157
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发表时间：
2018-02-28
期刊：
影响因子：
62.1
通讯作者：
Kong H
中科院分区：
文献类型：
--
作者：
Park J;Andrade B;Seo Y;Kim MJ;Zimmerman SC;Kong H
生物细胞是复杂的活机器，因其作为新一代治疗和递送剂的潜力而受到广泛关注。由于其分泌、分化和归巢活性，治疗细胞具有治疗甚至治愈传统治疗策略无法解决的各种疾病和损伤的巨大潜力。治疗细胞可以全身或局部移植。此外，由于细胞能够表达结合特定组织标志物的受体，细胞正在被研究作为能够靶向运输的纳米或微米尺寸的药物载体。根据治疗靶点，这些细胞可能聚集在一起以促进细胞间粘附。尽管临床前研究取得了一些令人印象深刻的结果，但其更广泛的发展仍然存在一些障碍，例如控制其运输、植入、分泌以及在体内追踪它们的能力有限。此外，创建治疗细胞的特定空间组织仍然很困难。最近出现了通过用无数生物活性分子、纳米颗粒和微粒改造细胞表面来解决这些挑战的努力，从而提高细胞的治疗功效。这篇评论文章评估了为设计细胞表面而开发的各种技术。审查结束时应考虑进一步提高细胞表面工程质量的未来考虑因素。
Biological cells are complex living machines that have garnered significant attention for their potential to serve as a new generation of therapeutic and delivery agents. Because of their secretion, differentiation, and homing activities, therapeutic cells have tremendous potential to treat or even cure various diseases and injuries that have defied conventional therapeutic strategies. Therapeutic cells can be systemically or locally transplanted. In addition, with their ability to express receptors that bind specific tissue markers, cells are being studied as nano- or microsized drug carriers capable of targeted transport. Depending on the therapeutic targets, these cells may be clustered to promote intercellular adhesion. Despite some impressive results with preclinical studies, there remain several obstacles to their broader development, such as a limited ability to control their transport, engraftment, secretion and to track them in vivo. Additionally, creating a particular spatial organization of therapeutic cells remains difficult. Efforts have recently emerged to resolve these challenges by engineering cell surfaces with a myriad of bioactive molecules, nanoparticles, and microparticles that, in turn, improve the therapeutic efficacy of cells. This review article assesses the various technologies developed to engineer the cell surfaces. The review ends with future considerations that should be taken into account to further advance the quality of cell surface engineering.
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影响因子：
1.2
作者：
Blake, Deborah A.;Bovin, Nicolai V.;Henry, Stephen M.
通讯作者：
Henry, Stephen M.
影响因子：
14
作者：
Bhatia, Sumati;Lauster, Daniel;Haag, Rainer
通讯作者：
Haag, Rainer
影响因子：
14
作者：
Andreas, Kristin;Georgieva, Radostina;Ringe, Jochen
通讯作者：
Ringe, Jochen
影响因子：
5.2
作者：
Baksh, Dolores;Yao, Raphael;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.
DOI：
10.1111/j.1749-6632.1999.tb08506.x
发表时间：
1999-01-01
期刊：
BIOARTIFICIAL ORGANS II: TECHNOLOGY, MEDICINE, AND MATERIALS
影响因子：
--
作者：
Calafiore, R;Basta, G;Brunetti, P
通讯作者：
Brunetti, P