Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension.
Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension.
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DOI：
10.1007/s10286-020-00764-4
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发表时间：
2021-03
影响因子：
5.8
通讯作者：
Shibao, Cyndya A.
中科院分区：
文献类型：
--
作者：
Giza, Richard J.;Farrell, Maureen C.;Arnold, Amy C.;Biaggioni, Italo;Shibao, Cyndya A.
关键词：
Neurogenic orthostatic hypotension (nOH) is the hallmark of neurodegenerative forms of autonomic failure, such as pure autonomic failure, multiple system atrophy and Parkinson’s disease. Studies have shown autonomic physiological differences in Africans Americans (AA) such as lower heart rate variability, enhanced blood pressure reactivity and blunted sympathetic neural response compared to non-Hispanic whites. However, the clinical characteristics and neurohormonal profile of autonomic failure in AA is unknown. A total of 65 patients with nOH participated in this study (9 AA and 56 non-Hispanic whites). Both groups were of similar age and comorbidity status, and they underwent standardized autonomic testing and assessment of neurohormonal levels and renin activity and aldosterone in supine and upright positions. There were no significant differences in baseline autonomic clinical characteristics between non-Hispanic whites and AA with nOH. Non-Hispanic whites demonstrated a significant increase in upright renin activity compared to AA (295 ± 88% vs. 13 ± 13%, respectively). AA showed a blunted increase in aldosterone compared to non-Hispanic whites (188 ± 27% vs. 59 ± 38%, respectively). These results indicated persistent suppression of the renin-angiotensin system in AA, particularly during upright posture. Our findings demonstrate that AA with nOH have similar clinical characteristics and hemodynamic autonomic profiles, but lower upright renin activity and aldosterone levels compared to non-Hispanic whites. Renin suppression persist in AA with severe autonomic failure and can potentially contribute to postural changes and supine hypertension.
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影响因子：
3
作者：
Murro, Diana G.;Beavers, Melinda;Kapuku, Gaston K.
通讯作者：
Kapuku, Gaston K.
DOI：
10.1007/s10286-015-0307-9
发表时间：
2015-10
期刊：
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
影响因子：
--
作者：
Celedonio JE;Arnold AC;Dupont WD;Ramirez CE;Diedrich A;Okamoto LE;Raj SR;Robertson D;Peltier AC;Biaggioni I;Shibao CA
通讯作者：
Shibao CA
神经源性体性低血压：病理生理，评估和管理。
影响因子：
6
作者：
Metzler M;Duerr S;Granata R;Krismer F;Robertson D;Wenning GK
通讯作者：
Wenning GK
影响因子：
8.3
作者：
El-Gharbawy, AH;Nadig, VS;Kotchen, TA
通讯作者：
Kotchen, TA
影响因子：
19.6
作者：
Wagner, C;Jensen, BL;Kurtz, A
通讯作者：
Kurtz, A