Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management.
Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management.
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神经源性体性低血压:病理生理,评估和管理。
DOI:
10.1007/s00415-012-6736-7
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发表时间:
2013-09
影响因子:
6
通讯作者:
Wenning GK
中科院分区:
文献类型:
--
作者:
Metzler M;Duerr S;Granata R;Krismer F;Robertson D;Wenning GK
Neurogenic orthostatic hypotension is a distinctive and treatable sign of cardiovascular autonomic dysfunction. It is caused by failure of noradrenergic neurotransmission that is associated with a range of primary or secondary autonomic disorders, including pure autonomic failure, Parkinson’s disease with autonomic failure, multiple system atrophy as well as diabetic and nondiabetic autonomic neuropathies. Neurogenic orthostatic hypotension is commonly accompanied by autonomic dysregulation involving other organ systems such as the bowel and the bladder. In the present review, we provide an overview of the clinical presentation, pathophysiology, epidemiology, evaluation and management of neurogenic orthostatic hypotension focusing on neurodegenerative disorders.
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