Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells.
Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells.
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DOI：
10.1007/s00167-011-1607-9
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发表时间：
2012-02
影响因子：
3.8
通讯作者：
Pellanda, Roberto
中科院分区：
文献类型：
--
作者：
Ellera Gomes, Joao L.;da Silva, Ricardo Canquerini;Silla, Lucia M. R.;Abreu, Marcelo R.;Pellanda, Roberto
目的探讨自体骨髓单个核细胞（BMMC）辅助下常规修复技术治疗肩袖撕裂的行为。连续14例肩袖完全撕裂（平均术前UCLA评分为12 ± 3.0）的患者（9例女性，5例男性，平均年龄59.2岁）通过小切口经骨缝合固定，随后将BMMC注射到手术前从髂嵴获得的肌腱边缘。术前和术后采集磁共振图像（MRI），并由两名肌肉骨骼放射科医生评价接受BMMC治疗患者的术后新发现。在至少12个月的随访期后，UCLA评分从12 ± 3.0增加到31 ± 3.2。除1例患者（13/14）外，所有患者的临床结果在第二年保持不变。随访12个月后的MRI分析显示所有病例（14/14）的肌腱完整性，8例（8/14）冈上肌腱和远端肌腹沿着存在低信号区，11例（11/14）在囊和肌腱地形图处存在高信号晕状小圆伪影。6例（6/14）患者显示在临界区形成高信号区。在接下来的一年中，除了一名患者外，所有患者的临床结果保持不变，该患者复发，失去力量和疼痛，被认为是不良结果。在肩袖缝线中植入BMMC似乎是目前用于提高受影响肌腱组织质量的其他生物学方法的安全且有前景的替代方法。四.
To investigate the behavior of rotator cuff tears treated with conventional repair technique with the aid of autologous bone marrow mononuclear cells (BMMC). Fourteen consecutive patients (9 women, 5 men, mean age of 59.2 years) with complete rotator cuff tears (mean preoperative UCLA score of 12 ± 3.0) were fixed by transosseous stitches through mini-open incision, with subsequent injection of BMMC into the tendon borders, obtained from the iliac crest just prior to surgery. Magnetic resonance images (MRI) were acquired before and after surgery and evaluated by two musculoskeletal radiologists regarding new postoperative findings of patients treated with BMMC. After a minimum 12-month follow-up period, the UCLA score increased from 12 ± 3.0 to 31 ± 3.2. Clinical findings remained unaltered in the following year in all but one patient (13/14). MRI analysis after a 12-month follow-up period demonstrated tendon integrity in all cases (14/14), presence of low-signal intensity areas along the supraspinatus tendon and distal muscle belly in 8 cases (8/14), and high-intensity blooming small round artifact at the bursal and tendon topography in 11 cases (11/14). Six patients (6/14) showed formation of a high-signal intensity zone at the critical zone. Clinical findings remained unaltered in the following year in all but one patient, who relapsed into loss of strength and pain, being considered a bad result. Implantation of BMMC in rotator cuff sutures appears to be a safe and promising alternative to other biological approaches currently used to enhance tissue quality in affected tendons. IV.
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DOI：
10.2106/00004623-199274100-00009
发表时间：
1992-12-01
影响因子：
5.3
作者：
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通讯作者：
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DOI：
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DOI：
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发表时间：
2003-07-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Caplan, AI
通讯作者：
Caplan, AI
影响因子：
4.8
作者：
GOBLE, EM;SOMERS, WK;OLSEN, RE
通讯作者：
OLSEN, RE