pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.
pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.
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DOI：
10.1038/jid.2008.442
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发表时间：
2009-07
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为了确定色素类型是否决定表皮功能的差异，我们研究了三个地理上不同的I-II型和IV-V型皮肤人群角质层（SC）的pH、渗透性屏障稳态和SC完整性（Fitzpatrick I-VI量表）。IV-V型受试者表现：(i)表面pH值较低（≈0.5 U）；（ii） SC完整性增强（经皮失水变化与连续胶带剥离）；（iii）比I-II型受试者更快的屏障恢复。屏障功能的增强可归因于表皮脂质含量的增加、板层体生成的增加和酸度的降低，从而导致脂质加工的增强。I-II型患者SC完整性受损可归因于丝氨酸蛋白酶活性增加，导致促丝粒蛋白-1 (DSG-1)/角膜促丝粒降解加速。相比之下，dsg -1阳性CDs在IV-V型受试者中持续存在，但由于组织蛋白酶- d活性增强，SC厚度没有增加。将I-II型SC的pH值调整到IV-V型水平可改善表皮功能。最后，来自IV-V型黑色素细胞的树突比来自I-II型受试者的树突酸性更强，并且它们向SC转移了更多的黑素小体，这表明黑素小体的分泌可能导致IV-V型皮肤的酸性pH值更高。这些研究表明，表皮结构和功能中色素类型的显著差异是由pH驱动的。
To determine whether pigment type determines differences in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in three geographically disparate populations with pigment type I–II versus IV–V skin (Fitzpatrick I–VI scale). Type IV–V subjects showed: (i) lower surface pH (≈0.5 U); (ii) enhanced SC integrity (transepidermal water loss change with sequential tape strippings); and (iii) more rapid barrier recovery than type I–II subjects. Enhanced barrier function could be ascribed to increased epidermal lipid content, increased lamellar body production, and reduced acidity, leading to enhanced lipid processing. Compromised SC integrity in type I–II subjects could be ascribed to increased serine protease activity, resulting in accelerated desmoglein-1 (DSG-1)/corneodesmosome degradation. In contrast, DSG-1-positive CDs persisted in type IV–V subjects, but due to enhanced cathepsin-D activity, SC thickness did not increase. Adjustment of pH of type I–II SC to type IV–V levels improved epidermal function. Finally, dendrites from type IV–V melanocytes were more acidic than those from type I–II subjects, and they transfer more melanosomes to the SC, suggesting that melanosome secretion could contribute to the more acidic pH of type IV–V skin. These studies show marked pigment-type differences in epidermal structure and function that are pH driven.
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影响因子：
3.6
作者：
Demerjian, M;Man, MQ;Feingold, KR
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