Modulation of bovine placental prostaglandin synthesis by an endogenous inhibitor.
Modulation of bovine placental prostaglandin synthesis by an endogenous inhibitor.
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内源性抑制剂对牛胎盘前列腺素合成的调节。
作者：
M. Shemesh;W. Hansel;J. Strauss
研究了牛胎盘体母源肉阜组织中一种内源性、热不稳定性前列腺素类合成抑制剂。在妊娠第120-250天的肉阜提取物中存在抑制活性，但在足月（260-280天）时未检测到。抑制活性的消失与前列腺素类分泌的增加相一致，由分散的肉阜细胞培养。共培养的肉阜细胞从胎盘的120天的妊娠胎儿子叶细胞导致前列腺素合成的子叶细胞的抑制。然而，这种抑制没有观察到分散的肉阜细胞和胎儿子叶细胞从长期胎盘共培养。我们的研究结果表明，内源性抑制剂调节牛胎盘前列腺素的合成。这种抑制剂水平的下降可能是触发分娩所需的前列腺素合成增加的一个因素。
An endogenous, heat-labile, inhibitor of prostanoid synthesis in maternal caruncle tissue of bovine placentomes was studied. Inhibitory activity was present in caruncle extracts from days 120-250 of gestation, but was not detectable at term (260-280 days). The disappearance of inhibitory activity coincided with an increase in the secretion of prostanoids by dispersed caruncle cells in culture. Coculture of caruncle cells from placentomes of 120-day gestation with fetal cotyledon cells resulted in suppression of prostanoid synthesis by the cotyledon cells. However, this inhibition was not observed in cocultures of dispersed caruncle cells and fetal cotyledon cells from term placentomes. Our findings indicate that an endogenous inhibitor modulates bovine placental prostaglandin synthesis. A decline in the level of this inhibitor at term may be one factor triggering increased prostanoid synthesis required for parturition.
人羊水对前列腺素合成的抑制：分娩过程中羊水的抑制活性急剧降低。
DOI：
10.1210/jcem-55-4-801
发表时间：
1982
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Saeed,SA;Strickland,DM;Young,DC;Dang,A;Mitchell,MD
通讯作者：
Mitchell,MD
人类胎儿尿液刺激前列腺素生物合成可能会触发分娩。
DOI：
10.1126/science.6573023
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Strickland,DM;Saeed,SA;Casey,ML;Mitchell,MD
通讯作者：
Mitchell,MD