Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible.
Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible.
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DOI：
10.1093/molbev/msv002
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发表时间：
2015-04
影响因子：
10.7
通讯作者：
Brenner SE
中科院分区：
文献类型：
--
作者：
Lareau LF;Brenner SE
Ultraconserved elements, unusually long regions of perfect sequence identity, are found in genes encoding numerous RNA-binding proteins including arginine-serine rich (SR) splicing factors. Expression of these genes is regulated via alternative splicing of the ultraconserved regions to yield mRNAs that are degraded by nonsense-mediated mRNA decay (NMD), a process termed unproductive splicing. As all human SR genes are affected by alternative splicing and NMD, one might expect this regulation to have originated in an early SR gene and persisted as duplications expanded the SR family. But in fact, unproductive splicing of most human SR genes arose independently. This paradox led us to investigate the origin and proliferation of unproductive splicing in SR genes. We demonstrate that unproductive splicing of the splicing factor SRSF5 (SRp40) is conserved among all animals and even observed in fungi; this is a rare example of alternative splicing conserved between kingdoms, yet its effect is to trigger mRNA degradation. As the gene duplicated, the ancient unproductive splicing was lost in paralogs, and distinct unproductive splicing evolved rapidly and repeatedly to take its place. SR genes have consistently employed unproductive splicing, and while it is exceptionally conserved in some of these genes, turnover in specific events among paralogs shows flexible means to the same regulatory end.
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影响因子：
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通讯作者：
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影响因子：
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影响因子：
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