Evolution of SR protein and hnRNP splicing regulatory factors.
Evolution of SR protein and hnRNP splicing regulatory factors.
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DOI：
10.1002/wrna.100
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发表时间：
2012-01
影响因子：
7.3
通讯作者：
Hertel, Klemens J.
中科院分区：
文献类型：
--
作者：
Busch, Anke;Hertel, Klemens J.
前体mRNA的剪接是真核生物基因表达的重要步骤。内含子通过剪接体的活动从分裂基因中去除，剪接体是一种在整个真核细胞谱系中保守的大型核糖核机器。虽然单细胞真核生物的特征在于较不复杂的剪接，但多细胞生物的前体mRNA剪接通常与显著丰富其蛋白质组的广泛的选择性剪接相关。剪接位点和外显子的选择允许多细胞生物以细胞类型特异性方式调节基因表达模式，从而有助于其功能多样化。选择性剪接是一个受调控的过程，主要受剪接调节因子（如SR蛋白或hnRNP）活性的影响。这些模块化因子已经从一个共同的祖先通过基因复制事件演变成一组不同的剪接调节因子，其通过与前mRNA的序列特异性结合来介导外显子识别。考虑到内含子扩增、前mRNA剪接的复杂性和剪接调节子的出现之间的强相关性，有人认为SR和hnRNP蛋白的增加通过放松剪接点的序列要求促进了选择性剪接的进化。
The splicing of pre-mRNAs is an essential step of gene expression in eukaryotes. Introns are removed from split genes through the activities of the spliceosome, a large ribonuclear machine that is conserved throughout the eukaryotic lineage. While unicellular eukaryotes are characterized by less complex splicing, pre-mRNA splicing of multicellular organisms is often associated with extensive alternative splicing that significantly enriches their proteome. The alternative selection of splice sites and exons permits multicellular organisms to modulate gene expression patterns in a cell type specific fashion, thus contributing to their functional diversification. Alternative splicing is a regulated process that is mainly influenced by the activities of splicing regulators, such as SR proteins or hnRNPs. These modular factors have evolved from a common ancestor through gene duplication events to a diverse group of splicing regulators that mediate exon recognition through their sequence specific binding to pre-mRNAs. Given the strong correlations between intron expansion, the complexity of pre-mRNA splicing, and the emergence of splicing regulators, it is argued that the increased presence of SR and hnRNP proteins promoted the evolution of alternative splicing through relaxation of the sequence requirements of splice junctions.
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影响因子：
64.5
作者：
Cooper TA;Wan L;Dreyfuss G
通讯作者：
Dreyfuss G
影响因子：
10.5
作者：
Blencowe, BJ;Issner, R;Sharp, PA
通讯作者：
Sharp, PA
影响因子：
4.5
作者：
Han, Siew Ping;Kassahn, Karin S.;Smith, Ross
通讯作者：
Smith, Ross
DOI：
10.1073/pnas.81.23.7471
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CHOI, YD;DREYFUSS, G
通讯作者：
DREYFUSS, G
影响因子：
16.8
作者：
House, Amy E.;Lynch, Kristen W.
通讯作者：
Lynch, Kristen W.