Effect of biannual azithromycin distribution on antibody responses to malaria, bacterial, and protozoan pathogens in Niger.
Effect of biannual azithromycin distribution on antibody responses to malaria, bacterial, and protozoan pathogens in Niger.
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DOI：
10.1038/s41467-022-28565-5
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发表时间：
2022-02-21
影响因子：
16.6
通讯作者：
MORDOR-Niger Study Group
中科院分区：
文献类型：
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作者：
Arzika AM;Maliki R;Goodhew EB;Rogier E;Priest JW;Lebas E;O'Brien KS;Le V;Oldenburg CE;Doan T;Porco TC;Keenan JD;Lietman TM;Martin DL;Arnold BF;MORDOR-Niger Study Group
在尼日尔、马拉维和坦桑尼亚进行的MORDOR试验发现，每年两次向5岁以下儿童大规模分发阿奇霉素可使全因死亡率降低13.5% （NCT02048007）。为了帮助阐明降低死亡率的机制，我们报告了在尼日尔农村30个社区进行的为期三年的安慰剂对照试验（n = 5642份血液样本，n = 3814名1-59个月的儿童）中，使用预先指定的多头测定法对11种疟疾、细菌和原生动物病原体的IgG反应。大量阿奇霉素使弯曲杆菌的感染力降低了29%（危险比= 0.71,95% CI: 0.56, 0.89; P = 0.004），但血清学测量显示，在高传播背景下，其他病原体的组间无显著差异。结果与最近在社区进行的一项微生物组研究相一致。鉴于弯曲杆菌感染在学龄前儿童中有显著的后遗症，我们的研究结果支持了一种重要的机制，通过这种机制，每年两次的阿奇霉素大规模分布可能会降低尼日尔的死亡率。在尼日尔农村的一项随机安慰剂对照试验中，一年两次给1-59个月大的儿童分发阿奇霉素降低了全因死亡率。基于血清学，Arzika等人报告了弯曲杆菌感染的减少，支持干预对死亡率影响的一种机制。
The MORDOR trial in Niger, Malawi, and Tanzania found that biannual mass distribution of azithromycin to children younger than 5 years led to a 13.5% reduction in all-cause mortality (NCT02048007). To help elucidate the mechanism for mortality reduction, we report IgG responses to 11 malaria, bacterial, and protozoan pathogens using a multiplex bead assay in pre-specified substudy of 30 communities in the rural Niger placebo-controlled trial over a three-year period (n = 5642 blood specimens, n = 3814 children ages 1–59 months). Mass azithromycin reduces Campylobacter spp. force of infection by 29% (hazard ratio = 0.71, 95% CI: 0.56, 0.89; P = 0.004) but serological measures show no significant differences between groups for other pathogens against a backdrop of high transmission. Results align with a recent microbiome study in the communities. Given significant sequelae of Campylobacter infection among preschool aged children, our results support an important mechanism through which biannual mass distribution of azithromycin likely reduces mortality in Niger. In a randomized placebo-controlled trial in rural Niger, biannual azithromycin distribution to children 1-59 months reduced all-cause mortality. Based on serology, Arzika et al. here report a reduction of Campylobacter infection, supporting one mechanism for the intervention’s impact on mortality.
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DOI：
10.1016/s0140-6736(17)31758-0
发表时间：
2017-11-11
期刊：
Lancet (London, England)
影响因子：
--
作者：
Golding N;Burstein R;Longbottom J;Browne AJ;Fullman N;Osgood-Zimmerman A;Earl L;Bhatt S;Cameron E;Casey DC;Dwyer-Lindgren L;Farag TH;Flaxman AD;Fraser MS;Gething PW;Gibson HS;Graetz N;Krause LK;Kulikoff XR;Lim SS;Mappin B;Morozoff C;Reiner RC Jr;Sligar A;Smith DL;Wang H;Weiss DJ;Murray CJL;Moyes CL;Hay SI
通讯作者：
Hay SI
DOI：
10.1093/cid/ciw542
发表时间：
2016-11-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amour C;Gratz J;Mduma E;Svensen E;Rogawski ET;McGrath M;Seidman JC;McCormick BJ;Shrestha S;Samie A;Mahfuz M;Qureshi S;Hotwani A;Babji S;Trigoso DR;Lima AA;Bodhidatta L;Bessong P;Ahmed T;Shakoor S;Kang G;Kosek M;Guerrant RL;Lang D;Gottlieb M;Houpt ER;Platts-Mills JA;Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
通讯作者：
Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
影响因子：
7.7
作者：
Knee J;Sumner T;Adriano Z;Anderson C;Bush F;Capone D;Casmo V;Holcomb D;Kolsky P;MacDougall A;Molotkova E;Braga JM;Russo C;Schmidt WP;Stewart J;Zambrana W;Zuin V;Nalá R;Cumming O;Brown J
通讯作者：
Brown J
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
34.3
作者：
Kotloff, Karen L.;Nasrin, Dilruba;Levine, Myron M.
通讯作者：
Levine, Myron M.