T cells in mycobacterial infection and disease.

T cells in mycobacterial infection and disease.
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DOI:
10.1016/j.coi.2009.06.004
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发表时间:
2009-08
影响因子:
7
通讯作者:
Cooper AM
Cooper AM
中科院分区:
医学2区
文献类型:
--
作者:
Cooper AM

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最近,我们对T细胞对分枝杆菌感染反应的复杂性的了解有所增加。改进的工具已经可以确定小鼠初始T细胞激活的位置和动力学,以及人类分支杆菌特异性细胞的各种功能。在分枝杆菌感染期间,抗菌活性和免疫病理反应控制之间的平衡也得到了越来越多的重视。将T细胞的功能数据与感染的后果结合起来,应该能改善合理的疫苗设计。
There has been an increase in our understanding of the complexity of the T cell response to mycobacterial infection recently. Improved tools have allowed determination of the location and kinetics of naive T cell activation in the mouse as well the variety of function of mycobacteria-specific cells in humans. There is also an increased appreciation of the balance required during mycobacterial infection between anti-bacterial activity and control of the immunopathologic response. The integration of the T cell functional data with the consequences of infection should improve rational vaccine design.
免疫相关的GTPase IRGM1通过防止干扰素γ诱导的细胞死亡促进活化的CD4+ T细胞群体的扩张。
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