Dynamic ubiquitin signaling in cell cycle regulation.
Dynamic ubiquitin signaling in cell cycle regulation.
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DOI：
10.1083/jcb.201703170
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发表时间：
2017-08-07
期刊：
影响因子：
--
通讯作者：
Peter M
中科院分区：
文献类型：
--
作者：
Gilberto S;Peter M
Gilberto 和 Peter 讨论了泛素化在 DNA 复制和有丝分裂调节中的作用。细胞分裂周期由协调 DNA 复制和分离的一系列酶驱动，确保基因组信息得到忠实且永久的保存。执行和协调这些生物过程的效应蛋白的活性通过调节表达和/或翻译后修饰而振荡。泛素化是一种重要的细胞修饰，长期以来因驱动细胞周期转变而闻名。在这篇综述中，我们强调了泛素化如何带来 DNA 复制和有丝分裂过程中必要的动态性和可塑性的新兴概念。新的研究通常集中于 DNA 聚合酶或动粒激酶等染色体蛋白的调节，表明泛素化是一种多功能修饰，可用于微调这些细胞周期事件，通常通过不涉及蛋白酶体降解的过程。了解越来越多的已识别泛素信号是如何转导的，将使我们能够对多种因素如何结合在一起以忠实地传播基因组信息形成更深入的机制认识。在这里，我们讨论这些以及目前正在研究的其他概念性挑战，以了解泛素如何控制细胞周期调节。
Gilberto and Peter discuss the role of ubiquitylation in the regulation of DNA replication and mitosis. The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication and separation, ensuring that genomic information is faithfully and perpetually maintained. The activity of the effector proteins that perform and coordinate these biological processes oscillates by regulated expression and/or posttranslational modifications. Ubiquitylation is a cardinal cellular modification and is long known for driving cell cycle transitions. In this review, we emphasize emerging concepts of how ubiquitylation brings the necessary dynamicity and plasticity that underlie the processes of DNA replication and mitosis. New studies, often focusing on the regulation of chromosomal proteins like DNA polymerases or kinetochore kinases, are demonstrating that ubiquitylation is a versatile modification that can be used to fine-tune these cell cycle events, frequently through processes that do not involve proteasomal degradation. Understanding how the increasing variety of identified ubiquitin signals are transduced will allow us to develop a deeper mechanistic perception of how the multiple factors come together to faithfully propagate genomic information. Here, we discuss these and additional conceptual challenges that are currently under study toward understanding how ubiquitin governs cell cycle regulation.
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