The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.
The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.
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DOI：
10.1016/j.bbamcr.2013.02.028
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发表时间：
2014-01
影响因子：
5.1
通讯作者：
Pagano, Michele
中科院分区：
文献类型：
--
作者：
Bassermann, Florian;Eichner, Ruth;Pagano, Michele
E3泛素连接酶的两个家族在细胞周期调控中是突出的，并且介导关键细胞周期蛋白的及时和精确的泛素-蛋白酶体依赖性降解：SCF（Skp 1/Cul 1/F-box蛋白）复合物和APC/C（后期促进复合物或环体）。虽然某些SCF连接酶在整个细胞周期中驱动细胞周期进程，但APC/C（与两种底物招募蛋白Cdc 20和Cdh 1中的任一种复合）协调退出有丝分裂（APC/CCdc 20）并建立稳定的G1期（APC/Cdh 1）。在DNA损伤或正常细胞周期扰动时，两种连接酶都参与检查点激活。在过去的十年中，对这些过程的机制洞察已经得到了显着改善，这主要是由于对APC/C和多种F-box蛋白（SCF连接酶的可变底物招募组分）的功能表征有了更好的理解。在这里，我们回顾了SCF和APC/C介导的泛素化在正常和扰动的细胞周期中的作用，并讨论了SCF和APC/C功能的潜在临床意义。
Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the timely and precise ubiquitin-proteasome-dependent degradation of key cell cycle proteins: the SCF (Skp1/Cul1/F-box protein) complex and the APC/C (Anaphase Promoting Complex or Cyclosome). While certain SCF ligases drive cell cycle progression throughout the cell cycle, APC/C (in complex with either of two substrate recruiting proteins: Cdc20 and Cdh1) orchestrates exit from mitosis (APC/CCdc20) and establishes a stable G1 phase (APC/CCdh1). Upon DNA damage or perturbation of the normal cell cycle, both ligases are involved in checkpoint activation. Mechanistic insight into these processes has significantly improved over the last ten years, largely due to a better understanding of APC/C and the functional characterization of multiple F-box proteins, the variable substrate recruiting components of SCF ligases. Here, we review the role of SCF- and APC/C-mediated ubiquitylation in the normal and perturbed cell cycle and discuss potential clinical implications of SCF and APC/C functions.
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影响因子：
21.3
作者：
通讯作者：
--
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
64.5
作者：
Bassermann, Florian;Frescas, David;Guardavaccaro, Daniele;Busino, Luca;Peschiaroli, Angelo;Pagano, Michele
通讯作者：
Pagano, Michele
影响因子：
50.3
作者：
Barbash, Olena;Zamfirova, Petia;Lin, Douglas I.;Chen, Xiangmei;Yang, Ke;Nakagawa, Hiroshi;Lu, Fengmin;Rustgi, Anil K.;Diehl, J. Alan
通讯作者：
Diehl, J. Alan
影响因子：
16
作者：
Abbas T;Shibata E;Park J;Jha S;Karnani N;Dutta A
通讯作者：
Dutta A