The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis.
The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis.
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DOI：
10.3389/fcell.2022.1096899
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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分泌途径是新合成的蛋白质跨越内质网（ER）、高尔基体、溶酶体和细胞表面进行囊泡运输的细胞内高速公路。多种货物受体、分子伴侣和质量控制蛋白维持货物沿着这条路线的顺畅流动。其中包括囊泡转运蛋白TMED 9，其属于p24/跨膜emp 24结构域（TMED）蛋白家族，并且在脊椎动物物种中表达。TMED家族由结构相关的I型跨膜蛋白组成，其具有管腔N-末端高尔基体动力学结构域、管腔卷曲螺旋结构域、跨膜结构域和结合COPI和COPII外壳蛋白的短胞质C-末端尾。与TMED家族的其他成员一样，TMED 9首先被鉴定为COPI和COPII包被的囊泡的丰富组分，所述囊泡介导ER和高尔基体之间的运输。TMED 9通常与TMED家族成员一起在异源寡聚体中纯化，这表明它可能作为复合物的一部分起作用。近年来，TMED家族成员被发现在分泌途径稳态中发挥多种作用，包括分泌蛋白加工、质量控制和错误折叠蛋白的降解以及高尔基体后运输。特别是，TMED 9与自噬，溶酶体分选，病毒复制和癌症有关，我们将在这篇迷你评论中讨论。
The secretory pathway is an intracellular highway for the vesicular transport of newly synthesized proteins that spans the endoplasmic reticulum (ER), Golgi, lysosomes and the cell surface. A variety of cargo receptors, chaperones, and quality control proteins maintain the smooth flow of cargo along this route. Among these is vesicular transport protein TMED9, which belongs to the p24/transmembrane emp24 domain (TMED) family of proteins, and is expressed across vertebrate species. The TMED family is comprised of structurally-related type I transmembrane proteins with a luminal N-terminal Golgi-dynamics domain, a luminal coiled-coil domain, a transmembrane domain and a short cytosolic C-terminal tail that binds COPI and COPII coat proteins. TMED9, like other members of the TMED family, was first identified as an abundant constituent of the COPI and COPII coated vesicles that mediate traffic between the ER and the Golgi. TMED9 is typically purified in hetero-oligomers together with TMED family members, suggesting that it may function as part of a complex. Recently, TMED family members have been discovered to play various roles in secretory pathway homeostasis including secreted protein processing, quality control and degradation of misfolded proteins, and post-Golgi trafficking. In particular, TMED9 has been implicated in autophagy, lysosomal sorting, viral replication and cancer, which we will discuss in this Mini-Review.
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作者：
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