Immune deviation: A historical perspective *
Immune deviation: A historical perspective *
复制标题
免疫偏差：历史视角*
作者：
C. Parish
在本文中，我回顾了我的早期研究，1966年和1976年之间，对免疫偏差的现象。最初总结了使用来自阿德莱德沙门氏菌的不同形式的鞭毛蛋白抗原的实验，这些实验建立了迟发型超敏反应（DTH）和抗体形成之间的反比关系。在鞭毛蛋白研究的基础上，阐明了决定抗原是否诱导DTH或抗体形成的许多关键因素。这些因素在今天与25年前一样重要。随后在细胞水平的分析表明，不同的T细胞亚群介导DTH和T细胞通过抑制机制帮助和维持免疫偏离。这一早期工作提出的一些基本问题仍然没有答案，并进行了讨论。这些包括引发免疫偏离的初级信号事件的性质、B细胞在偏离过程中的作用以及CD8+ T细胞抑制抗体产生的机制。
In this paper I have reviewed my early studies, between 1966 and 1976, on the phenomenon of immune deviation. Initially summarized are experiments with different forms of the flagellin antigen from Salmonella adelaide which established the inverse relationship between delayed‐type hypersensitivity (DTH) and antibody formation. Based on the flagellin studies, many of the key factors which determine whether an antigen will induce either DTH or antibody formation were delineated. These factors are just as relevant today as they were 25 years ago. Subsequent analyses at the cellular level demonstrated that different T cell subsets mediate DTH and T cell help and maintain immune deviation by suppressor mechanisms. A number of fundamental questions raised by this early work remain unanswered and are discussed. These include the nature of the primary signalling events which initiate immune deviation, the role of B cells in the deviating process and the mechanism by which CD8+ T cells suppress antibody production.
免疫反应中辅助 T 细胞的分化。
影响因子：
7
作者：
Reiner,SL;Seder,RA
通讯作者：
Seder,RA