LHRH-targeted nanogels as a delivery system for cisplatin to ovarian cancer.
LHRH-targeted nanogels as a delivery system for cisplatin to ovarian cancer.
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DOI：
10.1021/mp4003688
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发表时间：
2013-10-07
影响因子：
4.9
通讯作者：
Bronich TK
中科院分区：
文献类型：
--
作者：
Nukolova NV;Oberoi HS;Zhao Y;Chekhonin VP;Kabanov AV;Bronich TK
Targeted drug delivery using multifunctional polymeric nanocarriers is a modern approach for cancer therapy. Our purpose was to prepare targeted nanogels for selective delivery of chemotherapeutic agent cisplatin to luteinizing hormone-releasing hormone (LHRH) receptor overexpressing tumor in vivo. Building blocks of such delivery systems consisted of innovative soft block copolymer nanogels with ionic cores serving as a reservoir for cisplatin (loading 35%) and a synthetic analog of LHRH conjugated to the nanogels via poly(ethylene glycol) spacer. Covalent attachment of (D-Lys6)-LHRH to nanogels was shown to be possible without loss in either the ligand binding affinity or the nanogel drug incorporation ability. LHRH-nanogel accumulation was specific to the LHRH-receptor positive A2780 ovarian cancer cells and not towards LHRH-receptor negative SKOV-3 cells. The LHRH-nanogel cisplatin formulation was more effective and less toxic than equimolar doses of free cisplatin or untargeted nanogels in the treatment of receptor-positive ovarian cancer xenografts in mice. Collectively, the study indicates that LHRH mediated nanogel-cisplatin delivery is a promising formulation strategy for therapy of tumors that express the LHRH receptor.
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影响因子：
16.1
作者：
Chacko RT;Ventura J;Zhuang J;Thayumanavan S
通讯作者：
Thayumanavan S
DOI：
10.1073/pnas.0504274102
发表时间：
2005-09-06
影响因子：
11.1
作者：
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用于卵巢癌靶向治疗的叶酸装饰纳米凝胶。
影响因子：
14
作者：
Nukolova, Natalia V.;Oberoi, Hardeep S.;Cohen, Samuel M.;Kabanov, Alexander V.;Bronich, Tatiana K.
通讯作者：
Bronich, Tatiana K.
影响因子：
8
作者：
Oberoi HS;Nukolova NV;Laquer FC;Poluektova LY;Huang J;Alnouti Y;Yokohira M;Arnold LL;Kabanov AV;Cohen SM;Bronich TK
通讯作者：
Bronich TK