Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node.
Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node.
复制标题
缓解衰老、神经退行性和代谢性疾病中的细胞能量压力，SIRT1 作为治疗和有前途的节点。
DOI：
10.3389/fnagi.2021.738686
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发表时间：
2021
影响因子：
4.8
通讯作者：
Hua F
中科院分区：
文献类型：
--
作者：
Fang Y;Wang X;Yang D;Lu Y;Wei G;Yu W;Liu X;Zheng Q;Ying J;Hua F
细胞内的能量状态会在生理或病理刺激的影响下发生改变。为了响应这种变化，细胞通常动员各种分子及其机制，以促进细胞内能量状态的稳定。线粒体是ATP的主要来源。以往的研究发现，在衰老、神经退行性疾病和代谢性疾病中，线粒体的功能受损，线粒体受损导致ATP生成减少，从而进一步延缓疾病的进展。沉默信息调节因子-1（SIRT 1）是一种多能分子，参与细胞中重要生物学过程的调节，包括细胞代谢、细胞衰老和炎症。本文主要综述了促进SIRT 1的表达和活性有助于缓解生理和病理条件下产生的能量应激。本文还从多个方面探讨了SIRT 1表达和活性的精确调控机制。最后，根据这一机制在促进线粒体功能恢复方面的特点，分析了目前药物制剂与衰老、神经退行性疾病、代谢性疾病等疾病的关系。
The intracellular energy state will alter under the influence of physiological or pathological stimuli. In response to this change, cells usually mobilize various molecules and their mechanisms to promote the stability of the intracellular energy status. Mitochondria are the main source of ATP. Previous studies have found that the function of mitochondria is impaired in aging, neurodegenerative diseases, and metabolic diseases, and the damaged mitochondria bring lower ATP production, which further worsens the progression of the disease. Silent information regulator-1 (SIRT1) is a multipotent molecule that participates in the regulation of important biological processes in cells, including cellular metabolism, cell senescence, and inflammation. In this review, we mainly discuss that promoting the expression and activity of SIRT1 contributes to alleviating the energy stress produced by physiological and pathological conditions. The review also discusses the mechanism of precise regulation of SIRT1 expression and activity in various dimensions. Finally, according to the characteristics of this mechanism in promoting the recovery of mitochondrial function, the relationship between current pharmacological preparations and aging, neurodegenerative diseases, metabolic diseases, and other diseases was analyzed.
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影响因子：
20.8
作者：
Chini CCS;Peclat TR;Warner GM;Kashyap S;Espindola-Netto JM;de Oliveira GC;Gomez LS;Hogan KA;Tarragó MG;Puranik AS;Agorrody G;Thompson KL;Dang K;Clarke S;Childs BG;Kanamori KS;Witte MA;Vidal P;Kirkland AL;De Cecco M;Chellappa K;McReynolds MR;Jankowski C;Tchkonia T;Kirkland JL;Sedivy JM;van Deursen JM;Baker DJ;van Schooten W;Rabinowitz JD;Baur JA;Chini EN
通讯作者：
Chini EN
DOI：
10.1016/j.bbapap.2009.11.023
发表时间：
2010-08
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Dominy JE Jr;Lee Y;Gerhart-Hines Z;Puigserver P
通讯作者：
Puigserver P
DOI：
10.1038/s41580-020-00313-x
发表时间：
2021-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Covarrubias AJ;Perrone R;Grozio A;Verdin E
通讯作者：
Verdin E
影响因子：
4.8
作者：
Zhou Y;Wang S;Li Y;Yu S;Zhao Y
通讯作者：
Zhao Y
影响因子：
4
作者：
Carbonell, Felix;Zijdenbos, Alex P.;Bedell, Barry J.
通讯作者：
Bedell, Barry J.