Inappropriately sweet: Environmental endocrine-disrupting chemicals and the diabetes pandemic.
Inappropriately sweet: Environmental endocrine-disrupting chemicals and the diabetes pandemic.
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DOI：
10.1016/bs.apha.2021.04.002
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sargis RM
中科院分区：
文献类型：
--
作者：
Schulz MC;Sargis RM
糖尿病是一种慢性能量代谢紊乱，其特征在于高血糖症和其他代谢紊乱，导致显著的个体发病率和死亡率以及大量的医疗保健费用，困扰着全球数亿人。重要的是，糖尿病在美国的影响在人口中并不均匀;相反，有色人种和低收入群体受到的影响不成比例。虽然过量的热量摄入、缺乏运动和遗传易感性被认为是糖尿病风险的贡献者，但这些因素本身并不能完全解释全球糖尿病发病率的快速上升。近年来，环境污染物作为内分泌干扰物（EDCs）参与了糖尿病的发病机制。事实上，来自基于细胞、动物、群体甚至临床研究的新兴数据现在表明，天然和合成来源的各种结构不同的EDC具有改变胰岛素分泌和作用以及整体葡萄糖稳态的能力。本章回顾了在这一系列证据中将内分泌干扰物与糖尿病风险联系起来的证据。我们希望，提高我们对糖尿病发展的环境驱动因素的理解，将阐明新的个人层面和政策干预措施，以减轻这种破坏性疾病对弱势社区和广大人口的影响。
Afflicting hundreds of millions of individuals globally, diabetes mellitus is a chronic disorder of energy metabolism characterized by hyperglycemia and other metabolic derangements that result in significant individual morbidity and mortality as well as substantial healthcare costs. Importantly, the impact of diabetes in the United States is not uniform across the population; rather, communities of color and those with low income are disproportionately affected. While excessive caloric intake, physical inactivity, and genetic susceptibility are undoubted contributors to diabetes risk, these factors alone fail to fully explain the rapid global rise in diabetes rates. Recently, environmental contaminants acting as endocrine-disrupting chemicals (EDCs) have been implicated in the pathogenesis of diabetes. Indeed, burgeoning data from cell-based, animal, population, and even clinical studies now indicate that a variety of structurally distinct EDCs of both natural and synthetic origin have the capacity to alter insulin secretion and action as well as global glucose homeostasis. This chapter reviews the evidence linking EDCs to diabetes risk across this spectrum of evidence. It is hoped that improving our understanding of the environmental drivers of diabetes development will illuminate novel individual-level and policy interventions to mitigate the impact of this devastating condition on vulnerable communities and the population at large.
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