The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance.
The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance.
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DOI：
10.1289/ehp.8451
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发表时间：
2006-01
影响因子：
10.4
通讯作者：
Nadal A
中科院分区：
文献类型：
--
作者：
Alonso-Magdalena P;Morimoto S;Ripoll C;Fuentes E;Nadal A
胰腺β细胞的功能是储存和释放胰岛素，胰岛素是参与血糖稳态的主要激素。本文的研究结果表明，广泛存在的环境污染物双酚a （BPA）通过基因组和非基因组途径模拟了体内17β-雌二醇（E2）对血糖稳态的影响。成年小鼠暴露于单次低剂量（10 μg/kg）的E2或BPA诱导血糖迅速下降，与血浆胰岛素升高相关。长时间暴露于E2和BPA以雌激素受体依赖的方式诱导胰腺β细胞胰岛素含量增加。治疗2天后，开始剂量低至10 μg/kg/天，这种效果可见。用E2或BPA治疗4天后，这些小鼠出现了慢性高胰岛素血症，它们的葡萄糖和胰岛素耐量试验发生了改变。这些实验揭示了环境雌激素和胰岛素抵抗之间的联系。因此，无论是内源性雌激素水平异常还是环境雌激素暴露都会增加2型糖尿病、高血压和血脂异常的风险。
The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 μg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E2 and BPA induce an increase in pancreatic β-cell insulin content in an estrogen-receptor–dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 μg/kg/day. After 4 days of treatment with either E2 or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia.
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影响因子：
10.4
作者：
MacLusky NJ;Hajszan T;Leranth C
通讯作者：
Leranth C
影响因子：
15.9
作者：
Devedjian, JC;George, M;Bosch, F
通讯作者：
Bosch, F
影响因子：
15.9
作者：
COSTRINI, NV;KALKHOFF, RK
通讯作者：
KALKHOFF, RK
DOI：
10.1038/137996a0
发表时间：
1936-01-01
期刊：
NATURE [LONDON]
影响因子：
--
作者：
DODDS, E. C;LAWSON, WILFRED
通讯作者：
LAWSON, WILFRED
影响因子：
8.2
作者：
DELPRATO, S;LEONETTI, E;DEFRONZO, RA
通讯作者：
DEFRONZO, RA