Neuroprotective effect and potential of cellular prion protein and its cleavage products for treatment of neurodegenerative disorders part II: strategies for therapeutics development.
Neuroprotective effect and potential of cellular prion protein and its cleavage products for treatment of neurodegenerative disorders part II: strategies for therapeutics development.
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细胞朊蛋白及其裂解产物对神经退行性疾病的神经保护作用和治疗潜力第二部分：治疗学发展策略。
DOI：
10.1080/14737175.2021.1965882
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发表时间：
2021-09
影响因子：
4.3
通讯作者：
Kong Q
中科院分区：
文献类型：
--
作者：
Dexter E;Kong Q
细胞朊蛋白（PrPC），它的一些衍生物（特别是PrP N-末端N1肽和脱落PrP），和PrPC含有外泌体具有很强的神经保护活性，这已经在同伴文章（第一部分）中进行了综述，并简要总结在这里。我们建议，提高细胞外水平的保护性PrP形式，使用基因治疗和其他方法是一个非常有前途的新途径，对朊病毒病，阿尔茨海默氏病和其他几种神经退行性疾病的预防和治疗。我们将剖析各种潜在的基于PrP的治疗方案的利弊，并提出一些更有可能成功的策略。引用的参考文献来自PubMed对近期文献的广泛检索，包括同行评审的原始文章和综述文章。通过优化的基因治疗载体同时敲低细胞PrP表达和升高神经保护性PrP N-末端肽的细胞外水平是一种非常有前途的针对几种神经退行性疾病（包括朊病毒疾病、阿尔茨海默病和帕金森病）的广谱预防和治疗策略。
Cellular prion protein (PrPC), some of its derivatives (especially PrP N-terminal N1 peptide and shed PrP), and PrPC-containing exosomes have strong neuroprotective activities, which have been reviewed in the companion article (Part I) and are briefly summarized here. We propose that elevating the extracellular levels of a protective PrP form using gene therapy and other approaches is a very promising novel avenue for prophylactic and therapeutic treatments against prion disease, Alzheimer’s disease and several other neurodegenerative diseases. We will dissect the pros and cons of various potential PrP-based treatment options and propose a few strategies that are more likely to succeed. The cited references were obtained from extensive PubMed searches of recent literature, including peer-reviewed original articles and review articles. Concurrent knockdown of cellular PrP expression and elevation of the extracellular levels of a neuroprotective PrP N-terminal peptide via optimized gene therapy vectors is a highly promising broad-spectrum prophylactic and therapeutic strategy against several neurodegenerative diseases, including prion diseases, Alzheimer’s disease and Parkinson’s disease.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
α-突触核蛋白淀粉样蛋白劫持了prion蛋白以获得细胞的进入，促进细胞到细胞扩散并阻止prion复制。
影响因子：
4.6
作者：
Aulić S;Masperone L;Narkiewicz J;Isopi E;Bistaffa E;Ambrosetti E;Pastore B;De Cecco E;Scaini D;Zago P;Moda F;Tagliavini F;Legname G
通讯作者：
Legname G
影响因子：
11.1
作者：
Calella, Anna Maria;Farinelli, Melissa;Aguzzi, Adriano
通讯作者：
Aguzzi, Adriano
影响因子：
6.7
作者：
Chesebro B;Race B;Meade-White K;Lacasse R;Race R;Klingeborn M;Striebel J;Dorward D;McGovern G;Jeffrey M
通讯作者：
Jeffrey M
影响因子：
12.7
作者：
Corbett, Grant T.;Wang, Zemin;Walsh, Dominic M.
通讯作者：
Walsh, Dominic M.