ADHDgene: a genetic database for attention deficit hyperactivity disorder.
ADHDgene: a genetic database for attention deficit hyperactivity disorder.
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ADHDgene：注意力缺陷多动障碍基因数据库
DOI：
10.1093/nar/gkr992
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发表时间：
2012-01
影响因子：
14.9
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhang L;Chang S;Li Z;Zhang K;Du Y;Ott J;Wang J
注意缺陷多动障碍（ADHD）全球患病率约为5%，已成为最常见的精神障碍之一。ADHD的多基因特性表明，多个基因共同作用导致了这种复杂疾病的发生。近年来，旨在探究ADHD遗传易感性的研究不断增多。越来越有必要整合来自各类遗传学研究的遗传数据，以提供全面的数据集和统一的访问途径，方便进行深度数据挖掘。到目前为止，针对ADHD尚未有过此类尝试。为了解决ADHD的遗传复杂性问题，我们通过深入研读文献，整合与ADHD相关的遗传因素，开发了ADHDgene数据库。基于文献数据，我们开展了扩展功能分析，包括连锁不平衡分析、基于通路的分析以及基因定位，以期为ADHD的遗传病因提供新的见解。此外，我们还开发了功能强大的搜索工具和图形化浏览器，以方便数据浏览及数据关联查询。作为首个针对ADHD的遗传数据库，ADHDgene旨在为研究人员提供一个ADHD核心遗传资源与分析平台，可通过http://adhd.psych.ac.cn/免费访问 。
With a worldwide prevalence of ∼5%, attention deficit hyperactivity disorder (ADHD) has become one of the most common psychiatric disorders. The polygenetic nature of ADHD indicates that multiple genes jointly contribute to the development of this complex disease. Studies aiming to explore genetic susceptibility of ADHD have been increasing in recent years. There is a growing need to integrate the genetic data from various genetic studies to provide a comprehensive data set and uniform access for convenience of in-depth data mining. So far, there has been no such effort for ADHD. To address the genetic complexity of ADHD, we developed the ADHDgene database by integrating ADHD-related genetic factors by profound literature reading. Based on the data from the literature, extended functional analysis, including linkage disequilibrium analysis, pathway-based analysis and gene mapping were performed to provide new insights into genetic causes of ADHD. Moreover, powerful search tools and a graphical browser were developed to facilitate the navigation of the data and data connections. As the first genetic database for ADHD, ADHDgene aims to provide researchers with a central genetic resource and analysis platform for ADHD and is freely available at http://adhd.psych.ac.cn/.
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影响因子：
5.8
作者：
Liberzon, Arthur;Subramanian, Aravind;Mesirov, Jill P.
通讯作者：
Mesirov, Jill P.
影响因子：
5.3
作者：
Cubells JF;Sun X;Li W;Bonsall RW;McGrath JA;Avramopoulos D;Lasseter VK;Wolyniec PS;Tang YL;Mercer K;Pulver AE;Elston RC
通讯作者：
Elston RC
影响因子：
11
作者：
Brookes, K.;Xu, X.;Johansson, L.
通讯作者：
Johansson, L.
基于家庭的全基因组关联扫描注意力缺陷/多动症障碍。
DOI：
10.1016/j.jaac.2010.02.014
发表时间：
2010-09
影响因子：
13.3
作者：
Mick E;Todorov A;Smalley S;Hu X;Loo S;Todd RD;Biederman J;Byrne D;Dechairo B;Guiney A;McCracken J;McGough J;Nelson SF;Reiersen AM;Wilens TE;Wozniak J;Neale BM;Faraone SV
通讯作者：
Faraone SV
影响因子：
14.9
作者：
Basu SN;Kollu R;Banerjee-Basu S
通讯作者：
Banerjee-Basu S