Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.
Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.
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基于家庭的全基因组关联扫描注意力缺陷/多动症障碍。
DOI：
10.1016/j.jaac.2010.02.014
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发表时间：
2010-09
影响因子：
13.3
通讯作者：
Faraone SV
中科院分区：
文献类型：
--
作者：
Mick E;Todorov A;Smalley S;Hu X;Loo S;Todd RD;Biederman J;Byrne D;Dechairo B;Guiney A;McCracken J;McGough J;Nelson SF;Reiersen AM;Wilens TE;Wozniak J;Neale BM;Faraone SV
。基因可能在注意力缺陷多动障碍（ADHD）的病因学中发挥重要作用。然而，该疾病的遗传结构尚不清楚，之前的全基因组关联研究尚未发现全基因组显着关联。我们对 DSM-IV-TR ADHD 进行了第三次独立的多站点 GWAS。 。在马萨诸塞州总医院（MGH，N = 309 三人组）、圣路易斯华盛顿大学（WASH-U，N = 272 三人组）和加州大学洛杉矶分校（UCLA，N = 156 三人组）确定了家庭。使用 Illumina Human1M 或 Human1M-Duo BeadChip 平台进行基因分型。应用质量控制过滤器后，用来自 732 个家庭的 735 个 DSM-IV ADHD 三人组中的 835,136 个 SNP 测试了与 ADHD 的关联。 。我们的最小 p 值 (6.7E-07) 未达到全基因组统计显着性阈值 (5.0E-08)，但 20 个最显着关联之一位于 ADHD 感兴趣的候选基因中 (SLC9A9、rs9810857、p=6.4E-6)。我们还对文献中确定的候选基因进行了基于基因的测试，并发现了与 SLC9A9 相关的其他证据。 。我们和精神病学 GWAS 联盟的同事正在努力汇集 GWAS 样本，以建立跟踪这些结果所需的大型数据集，并识别 ADHD 和其他疾病的基因。
. Genes likely play a substantial role in the etiology of attention-deficit hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies have not identified a genome-wide significant association. We have conducted a third, independent multi-site GWAS of DSM-IV-TR ADHD. . Families were ascertained at Massachusetts General Hospital (MGH, N=309 trios), Washington University at St Louis (WASH-U, N=272 trios), and University of California at Los Angeles (UCLA, N=156 trios). Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. After applying quality control filters, association with ADHD was tested with 835,136 SNPs in 735 DSM-IV ADHD trios from 732 families. . Our smallest p-value (6.7E-07) did not reach the threshold for genome-wide statistical significance (5.0E-08) but one of the 20 most significant associations was located in a candidate gene of interest for ADHD, (SLC9A9, rs9810857, p=6.4E-6). We also conducted gene-based tests of candidate genes identified in the literature and found additional evidence of association with SLC9A9. . We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders.
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影响因子：
11
作者：
Brookes, K.;Xu, X.;Johansson, L.
通讯作者：
Johansson, L.
影响因子：
30.8
作者：
Levy, Daniel;Ehret, Georg B.;Rice, Kenneth;Verwoert, Germaine C.;Launer, Lenore J.;Dehghan, Abbas;Glazer, Nicole L.;Morrison, Alanna C.;Johnson, Andrew D.;Aspelund, Thor;Aulchenko, Yurii;Lumley, Thomas;Koettgen, Anna;Vasan, Ramachandran S.;Rivadeneira, Fernando;Eiriksdottir, Gudny;Guo, Xiuqing;Arking, Dan E.;Mitchell, Gary F.;Mattace-Raso, Francesco U. S.;Smith, Albert V.;Taylor, Kent;Scharpf, Robert B.;Hwang, Shih-Jen;Sijbrands, Eric J. G.;Bis, Joshua;Harris, Tamara B.;Ganesh, Santhi K.;O'Donnell, Christopher J.;Hofman, Albert;Rotter, Jerome I.;Coresh, Josef;Benjamin, Emelia J.;Uitterlinden, Andre G.;Heiss, Gerardo;Fox, Caroline S.;Witteman, Jacqueline C. M.;Boerwinkle, Eric;Wang, Thomas J.;Gudnason, Vilmundur;Larson, Martin G.;Chakravarti, Aravinda;Psaty, Bruce M.;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
DOI：
10.1097/00004583-200207000-00014
发表时间：
2002-07-01
影响因子：
13.3
作者：
Todd, RD;Sitdhiraksa, N;Neuman, RJ
通讯作者：
Neuman, RJ
DOI：
10.1002/ajmg.b.30860
发表时间：
2008-12-05
影响因子：
2.8
作者：
Sonuga-Barke, Edmund J. S.;Lasky-Su, Jessica;Faraone, Stephen V.
通讯作者：
Faraone, Stephen V.
影响因子：
30.8
作者：
Newton-Cheh, Christopher;Johnson, Toby;Gateva, Vesela;Tobin, Martin D.;Bochud, Murielle;Coin, Lachlan;Najjar, Samer S.;Zhao, Jing Hua;Heath, Simon C.;Eyheramendy, Susana;Papadakis, Konstantinos;Voight, Benjamin F.;Scott, Laura J.;Zhang, Feng;Farrall, Martin;Tanaka, Toshiko;Wallace, Chris;Chambers, John C.;Khaw, Kay-Tee;Nilsson, Peter;van der Harst, Pim;Polidoro, Silvia;Grobbee, Diederick E.;Onland-Moret, N. Charlotte;Bots, Michiel L.;Wain, Louise V.;Elliott, Katherine S.;Teumer, Alexander;Luan, Jian'an;Lucas, Gavin;Kuusisto, Johanna;Burton, Paul R.;Hadley, David;McArdle, Wendy L.;Brown, Morris;Dominiczak, Anna;Newhouse, Stephen J.;Samani, Nilesh J.;Webster, John;Zeggini, Eleftheria;Beckmann, Jacques S.;Bergmann, Sven;Lim, Noha;Song, Kijoung;Vollenweider, Peter;Waeber, Gerard;Waterworth, Dawn M.;Yuan, Xin;Groop, Leif;Orho-Melander, Marju;Allione, Alessandra;Di Gregorio, Alessandra;Guarrera, Simonetta;Panico, Salvatore;Ricceri, Fulvio;Romanazzi, Valeria;Sacerdote, Carlotta;Vineis, Paolo;Barroso, Ines;Sandhu, Manjinder S.;Luben, Robert N.;Crawford, Gabriel J.;Jousilahti, Pekka;Perola, Markus;Boehnke, Michael;Bonnycastle, Lori L.;Collins, Francis S.;Jackson, Anne U.;Mohlke, Karen L.;Stringham, Heather M.;Valle, Timo T.;Willer, Cristen J.;Bergman, Richard N.;Morken, Mario A.;Doering, Angela;Gieger, Christian;Illig, Thomas;Meitinger, Thomas;Org, Elin;Pfeufer, Arne;Wichmann, H. Erich;Kathiresan, Sekar;Marrugat, Jaume;O'Donnell, Christopher J.;Schwartz, Stephen M.;Siscovick, David S.;Subirana, Isaac;Freimer, Nelson B.;Hartikainen, Anna-Liisa;McCarthy, Mark I.;O'Reilly, Paul F.;Peltonen, Leena;Pouta, Anneli;de Jong, Paul E.;Snieder, Harold;van Gilst, Wiek H.;Clarke, Robert;Goel, Anuj;Hamsten, Anders;Peden, John F.;Seedorf, Udo;Syvanen, Ann-Christine;Tognoni, Giovanni;Lakatta, Edward G.;Sanna, Serena;Scheet, Paul;Schlessinger, David;Scuteri, Angelo;Doerr, Marcus;Ernst, Florian;Felix, Stephan B.;Homuth, Georg;Lorbeer, Roberto;Reffelmann, Thorsten;Rettig, Rainer;Voelker, Uwe;Galan, Pilar;Gut, Ivo G.;Hercberg, Serge;Lathrop, G. Mark;Zelenika, Diana;Deloukas, Panos;Soranzo, Nicole;Williams, Frances M.;Zhai, Guangju;Salomaa, Veikko;Laakso, Markku;Elosua, Roberto;Forouhi, Nita G.;Volzke, Henry;Uiterwaal, Cuno S.;van der Schouw, Yvonne T.;Numans, Mattijs E.;Matullo, Giuseppe;Navis, Gerjan;Berglund, Goran;Bingham, Sheila A.;Kooner, Jaspal S.;Connell, John M.;Bandinelli, Stefania;Ferrucci, Luigi;Watkins, Hugh;Spector, Tim D.;Tuomilehto, Jaakko;Altshuler, David;Strachan, David P.;Laan, Maris;Meneton, Pierre;Wareham, Nicholas J.;Uda, Manuela;Jarvelin, Marjo-Riitta;Mooser, Vincent;Melander, Olle;Loos, Ruth J. F.;Elliott, Paul;Abecasis, Goncalo R.;Caulfield, Mark;Munroe, Patricia B.
通讯作者：
Munroe, Patricia B.