The myeloid progenitor cell--its value in predicting hematopoietic recovery after autologous bone marrow transplantation.
The myeloid progenitor cell--its value in predicting hematopoietic recovery after autologous bone marrow transplantation.
复制标题
骨髓祖细胞——预测自体骨髓移植后造血恢复的价值。
作者：
G. Spitzer;D. Verma;Richard Fisher;A. Zander;Lyjda Vellekoop;J. Litam;Kenneth B. McCredie;K. Dicke
体外方法预测储存骨髓的充足性将具有临床价值。我们研究了CFU-C测定来预测大剂量治疗后的造血恢复。在急性白血病（AL）中，在首次缓解时收集骨髓，在实体瘤（ST）中，在先前治疗失败后收集骨髓。将骨髓储存在-192 ° C的液氮中。11例AL患者在移植前接受哌嗪二酮50 mg/m2和全身照射850 rads。ST患者（n = 13）接受环磷酰胺6 g/sq m，VP-16 500 mg/sq m和BCNU 300 mg/sq m。然后将骨髓解冻，并测定每10 s细胞输注的CFU-C数量。在ST患者中，TR后造血恢复与化疗前患者骨髓中CFU-C含量无关，但与CFU-C总数或CFU-C/kg输注有关。输注CFU-C/kg与中性粒细胞恢复至0.5 × 109/L之间的相关系数（cc）为-0.80（p9/L），与中性粒细胞恢复至0.5 × 109/L之间的相关系数（cc）为-0.833（p9/L），与中性粒细胞恢复至0.5 × 109/L之间的相关系数（cc）为-0.833（p9/L
In vitro methods to predict the adequacy of stored marrow would be clinically valuable. We investigated the CFU-C assay to predict for hematopoietic recovery after high-dose therapy. In acute leukemia (AL) marrow was collected in first remission and in solid tumor (ST) after failure of previous therapy. Marrow was stored in liquid nitrogen at –192°C. Before transplant (TR), patients with AL (n = 11) received piperazinedione 50 mg/sq m and total body irradiation 850 rads. Patients with ST (n = 13) received Cytoxan 6 g/sq m, VP-16 500 mg/sq m, and BCNU 300 mg/sq m. Marrow was then thawed, and the number of CFU-C per 10s cells infused determined. In patients with ST, hematopoietic recovery after TR was not related to CFU-C content in the patient’s marrow before chemotherapy, but to the total number of CFU-C or CFU-C/kg infused. The correlation coefficient (cc) between CFU-C/kg infused and neutrophil recovery to 0.5 × 10 9 /liter for AL = –0.80 (p 9 /liter = –0.833 (p
自体骨髓移植治疗复发性成人急性白血病。
DOI：
10.1007/978-3-642-67319-1_26
发表时间：
1980
期刊：
Haematology and blood transfusion
影响因子：
--
作者：
Dicke,KA;Zander,AR;Spitzer,G;Verma,DS;Peters,L;Vellekoop,L;Thomson,S;Stewart,D;McCredie,KB
通讯作者：
McCredie,KB