Autologous bone marrow transplantation in relapsed adult acute leukemia.
Autologous bone marrow transplantation in relapsed adult acute leukemia.
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自体骨髓移植治疗复发性成人急性白血病。
DOI：
10.1007/978-3-642-67319-1_26
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
McCredie,KB
中科院分区：
文献类型：
--
作者：
Dicke,KA;Zander,AR;Spitzer,G;Verma,DS;Peters,L;Vellekoop,L;Thomson,S;Stewart,D;McCredie,KB
1976年3月至1979年2月，采用大剂量化疗（哌嗪二酮）加超致死量全身照射（TBI）联合自体骨髓移植（ABMT）治疗成人急性白血病28例，其中24例可评价。在缓解时收集移植的骨髓细胞并储存在液氮中。在12例患者中，使用不连续白蛋白梯度分离骨髓细胞，试图从残留的白血病细胞中分离正常细胞。12例患者达到完全缓解（CR）;在另外9例患者中，植活迹象明显，但在达到CR前发生死亡。12例AML患者中有7例复发后首次接受骨髓移植治疗，达到CR。5例ALL患者中，4例在首次缓解时采集骨髓，达到CR。中位CR持续时间为4+个月，达到CR的患者中位生存期为6+个月。自体骨髓移植提供了一个很好的机会CR（66%），当骨髓收集在第一次缓解，并作为第一次治疗AML在第三次复发和ALL在第二次复发。
From March, 1976 to February, 1979, 28 cases of adult acute leukemia of which 24 were evaluable were treated in irreversible relapse with high dose chemotherapy (piperazinedione) and supra-lethal total body irradiation (TBI) in conjunction with autologous bone marrow transplantation (ABMT). The marrow cells grafted were collected and stored in liquid nitrogen at the time of remission. In 12 patients the marrow cells were fractionated using discontinuous albumin gradients in an attempt to separate normal cells from residual leukemic cells. Twelve patients achieved complete remission (CR); in 9 additional patients signs of engraftment were evident but death occurred before achievement of CR. Seven of 12 AML patients, which were treated with bone marrow transplantation as first treatment of their relapse, achieved CR. Four of 5 patients with ALL, whose bone marrows were collected during first remission, reached CR. The median CR duration was 4+ months and the median survival of the patients reaching CR was 6+ months. Autologous bone marrow transplantation offers a good chance of CR (66%), when marrow is collected during first remission and used as first treatment for AML in third relapse and ALL in second relapse.
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再生障碍性贫血和白血病的骨髓移植。
DOI：
--
发表时间：
1974
期刊：
Seminars in hematology (Print)
影响因子：
--
作者：
A. Fefer;E. Thomas;C. Buckner;R. Storb;P. Neiman;H. Glucksberg;R. Clift;K. Lerner
通讯作者：
K. Lerner
通过全身照射和静脉输注缓解期间获得的储存自体骨髓来治疗晚期白血病复发。
影响因子：
158.5
作者：
J. McGovern;P. Russell;L. Atkins;Webster Ew
通讯作者：
Webster Ew
一百名急性白血病患者接受化疗、全身照射和同种异体骨髓移植治疗。
影响因子：
20.3
作者：
Thomas Ed;Buckner Cd;M. Banaji;R. Clift;A. Fefer;N. Flournoy;B. Goodell;R. Hickman;Lerner Kg;P. Neiman;G. Sale;J. Sanders;J. Singer;M. Stevens;R. Storb;P. Weiden
通讯作者：
P. Weiden
核泡与人类急性白血病非整倍性的关联。
影响因子：
11.2
作者：
M. Ahearn;J. Trujillo;A. Cork;A. Fowler;J. Hart
通讯作者：
J. Hart
以植物血凝素为刺激因子的急性髓性白血病白血病细胞体外集落形成
影响因子：
64.8
作者：
K. Dicke;G. Spitzer;M. Ahearn
通讯作者：
M. Ahearn