Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review.
Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review.
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DOI：
10.1590/1516-4446-2015-1793
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发表时间：
2016-03-22
期刊：
影响因子：
--
通讯作者：
Gama CS
中科院分区：
文献类型：
--
作者：
Duarte JA;de Araújo E Silva JQ;Goldani AA;Massuda R;Gama CS
回顾双相情感障碍（BD）患者的弥散张量成像（DTI）的现有数据，特别关注白质束的分数各向异性（FA）。在PubMed/MEDLINE数据库中搜索相关文章，并将其纳入文献系统综述。FA减少和WM异常在解剖学上分为三组：联合束、联合束和投射束。18项研究符合纳入标准。胼胝体是联合束受损的主要部位，FA的减少证实了这一点。五项研究报告了扣带FA的减少。两项研究报告了丘脑前部辐射的FA减少，一项研究报告了皮质脊髓束的FA减少。相反，三项研究发现与双相障碍病理生理相关的WM束FA值升高。尽管存在相当大的异质性，但这些结果表明，缓解型双相障碍患者的执行认知功能与额边缘束WM微结构完整性异常之间存在直接联系，进一步证明了双相障碍症状学基础上的神经元破坏。
To review the available data on diffusion tensor imaging (DTI) of subjects with bipolar disorder (BD), with a particular focus on fractional anisotropy (FA) in white matter (WM) tracts. The PubMed/MEDLINE database was searched for relevant articles, which were included in a systematic review of the literature. FA reductions and WM abnormalities were divided anatomically into three groups: commissural tracts, association tracts, and projection tracts. Eighteen studies met the inclusion criteria. The corpus callosum was the main impaired commissural tract as demonstrated by FA reductions. Five studies reported FA reductions in the cingulum. Two studies reported decreased FA in the anterior thalamic radiation, and one in the corticospinal tract. Conversely, three studies found increased FA values in WM tracts involved in BD pathophysiology. Despite considerable heterogeneity, these results indicate a direct link between executive cognitive functioning and abnormal WM microstructural integrity of fronto-limbic tracts in patients with remitted BD, providing further evidence of the neuronal disruption that underlies BD symptomatology.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
5.3
作者：
Goldberg, JF;Ernst, CL
通讯作者：
Ernst, CL
影响因子：
3.3
作者：
Faria, Andreia V.;Oishi, Kenichi;Mori, Susumu
通讯作者：
Mori, Susumu
影响因子：
10.6
作者：
Emsell, Louise;Leemans, Alexander;McDonald, Colm
通讯作者：
McDonald, Colm
影响因子：
4.5
作者：
Ellison-Wright, Ian;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.