Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond.
Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond.
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DOI：
10.1016/j.semradonc.2008.09.009
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发表时间：
2009-01
影响因子：
3.5
通讯作者：
Grandis, Jennifer R.
中科院分区：
文献类型：
--
作者：
Harari, Paul M.;Wheeler, Deric L.;Grandis, Jennifer R.
2009年，美国将诊断出大约50，000例头颈部鳞状细胞癌（HNSCC）新发病例。虽然美国吸烟率的逐渐下降是一个非常有利的趋势，但未来全球HNSCC的发病率可能会反映出烟草产品在我们几个人口最多的国家的营销和渗透率的增加。虽然现代手术，放疗和常规化疗策略HNSCC继续提供逐步改善的结果，第一个分子靶向方法，以证明HNSCC患者的生存优势，最近出现在EGFR生物学的背景下。科学背景和当前的挑战，伴随着这一最新的进展是在这篇文章中描述的HNSCC的几个额外的有前途的分子靶点。有谨慎的预期，结合放射的分子靶向剂的逻辑进步可能会提供增加的治愈率和减少正常组织的毒性档案的HNSCC患者在未来几年。
Approximately 50,000 new cases of head and neck squamous cell carcinoma (HNSCC) will be diagnosed in the United States (US) in 2009. Whereas the gradual decline in smoking rates in the US is a highly favorable trend, future global HNSCC incidence will likely reflect the increased marketing and penetration of tobacco products across several of our most populous countries. Although modern surgery, radiation and conventional chemotherapy strategies for HNSCC continue to provide gradual improvement in outcome, the first molecular targeting approach to demonstrate a survival advantage for HNSCC patients has recently emerged in the context of EGFR biology. The scientific background and current challenges accompanying this recent advance are described in this article as are several additional promising molecular targets for HNSCC. There is cautious anticipation that the logical advancement of molecular targeting agents in conjunction with radiation may afford increased cure rates and diminished normal tissue toxicity profiles for HNSCC patients over the years to come.
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