Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation
Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation
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循环中间单核细胞和心房结构重塑与导管消融后心房颤动复发相关
DOI：
10.1111/jce.14929
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发表时间：
2021
影响因子：
2.7
通讯作者：
Yamashita Tom
中科院分区：
文献类型：
--
作者：
Suehiro Hideya;Kiuchi Kunihiko;Fukuzawa Koji;Yoshida Naofumi;Takami Mitsuru;Watanabe Yoshiaki;Izawa Yu;Akita Tomomi;Takemoto Makoto;Sakai Jun;Nakamura Toshihiro;Yatomi Atsusuke;Takahara Hiroyuki;Sonoda Yusuke;Nakasone Kazutaka;Yamamoto Kyoko;Yamashita Tom
背景炎症反应，如与中间型CD 14 ++ CD 16+单核细胞和心房结构重构（SRM）相关的炎症反应，可能在导管消融术后心房颤动（AF）复发中起重要作用。然而，中间CD14 ++ CD16+单核细胞，SRM，和AF复发之间的关系尚不清楚。在消融前通过流式细胞术评估中间单核细胞（PIM）的比例。作为SRM的替代标志物，计算了晚期钆增强磁共振成像（LGE-MRI）上信号强度大于1个标准差的体积比（VR）。我们研究了PIM是否与SRM LGE-MRI和确定最佳的截止值预测AF recurrence.ResultsUnivariate分析显示PIM和BNP与SRM之间呈正相关（PIM：r =.593，p =.002; BNP：r =.567，p =.004）。多变量分析显示，PIM与LGE-MRI上的VR独立相关（β = 0.522; p = 0.033）。受试者工作特征曲线下面积为0.750，表明LGE-MRI上VR ≥ 13.3%是预测AF复发的最佳临界值，其敏感性为80%，特异性为71%，与PIM ≥ 10.0%相关。PIM ≥ 10%与LGE-MRI上VR ≥ 13.3%相关，可预测导管消融后AF复发。
BackgroundInflammation, such as that associated with intermediate CD14++CD16+monocytes and atrial structural remodeling (SRM), may be important in the recurrence of atrial fibrillation (AF) after catheter ablation. However, the relationship between the intermediate CD14++CD16+monocytes, SRM, and AF recurrence is unclear.MethodsTwenty‐four patients with AF were enrolled. The proportion of intermediate monocytes (PIM) was assessed before ablation by flow cytometry. As a surrogate marker of SRM, the volume ratio (VR) of signal intensity greater than 1 standard deviation on late‐gadolinium enhancement magnetic resonance imaging (LGE‐MRI) was calculated. We investigated whether PIM correlated with SRM on LGE‐MRI and determined the optimal cutoff value for predicting AF recurrence.ResultsUnivariate analysis revealed positive correlations between PIM and BNP with SRM (PIM:r= .593,p= .002; BNP:r= .567,p= .004). Multivariable analysis revealed that PIM was independently associated with VR on LGE‐MRI (β= .522;p= .033). The finding of an area under the receiver operating characteristic curve of 0.750 revealed that a VR ≥ 13.3% on LGE‐MRI as the optimal cutoff value to predict AF recurrence with 80% sensitivity and 71% specificity, which was associated with PIM ≥ 10.0%.ConclusionIntermediate monocytes were significantly positively correlated with SRM. PIM ≥ 10% was associated with a VR ≥ 13.3% on LGE‐MRI, which predicted AF recurrence after catheter ablation.
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影响因子：
6.1
作者：
Suzuki, Atsushi;Fukuzawa, Koji;Hirata, Ken-ichi
通讯作者：
Hirata, Ken-ichi
影响因子：
3.7
作者：
Ghazal, Faris;Theobald, Holger;Al-Khalili, Faris
通讯作者：
Al-Khalili, Faris
炎症和氧化应激在心房颤动中的作用。
影响因子：
5.5
作者：
Li, Jie;Solus, Joseph;Chen, Qingxia;Rho, Young Hee;Milne, Ginger;Stein, C. Michael;Darbar, Dawood
通讯作者：
Darbar, Dawood
影响因子：
20.3
作者：
Zawada, Adam M.;Rogacev, Kyrill S.;Heine, Gunnar H.
通讯作者：
Heine, Gunnar H.
DOI：
10.1152/ajpheart.00733.2004
发表时间：
2005-10-01
影响因子：
4.8
作者：
Saba, S;Janczewski, AM;London, B
通讯作者：
London, B