Role of inflammation and oxidative stress in atrial fibrillation.
Role of inflammation and oxidative stress in atrial fibrillation.
复制标题
炎症和氧化应激在心房颤动中的作用。
DOI：
10.1016/j.hrthm.2009.12.009
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发表时间：
2010-04
期刊：
影响因子：
5.5
通讯作者：
Darbar, Dawood
中科院分区：
文献类型：
--
作者：
Li, Jie;Solus, Joseph;Chen, Qingxia;Rho, Young Hee;Milne, Ginger;Stein, C. Michael;Darbar, Dawood
心房颤动（AF）是临床上最常见的心律失常。越来越多的证据表明，炎症和氧化应激与房颤的发病机制有关，但它们的作用仍不明确。此外，尚不清楚炎症和氧化应激是否与特定类型的房颤相关。本研究的目的是确定炎症和氧化应激在房颤中的作用。采用病例对照研究设计，将305例房颤患者与150例对照患者进行比较。测定血清白细胞介素(IL)-6、IL-8、IL-10、肿瘤坏死因子(TNF)-α、单核细胞趋化蛋白(MCP)-1、血管内皮生长因子（VEGF）、n端前脑利钠肽（NTpBNP）和尿f2 -异前列腺素（氧化应激指标）的浓度。IL-6、IL-8、IL-10、TNF-α、MCP1、VEGF和NTpBNP浓度与AF独立相关（P值均<0.05），但f2 -异前列腺素排泄量未升高（P=0.50）。发作性、持续性和永久性房颤动亚组中TNF-α（中位数[四分位数间距（IQR）]: 6.8[3.4-11.3]、8.0[5.6-10.9]、10.1 [5.7-12.4]pg/ml， P<0.05）和NTpBNP（170.6[67.3-481.9]、681.39[310.3-1439.0]、1179.9 [653.1-2096.0]pg/ml， P<0.001）分别呈分级升高。这项研究表明，AF患者的炎症生物标志物显著增加，支持炎症与心律失常之间的强烈关联。令人惊讶的是，尿f2 -异前列腺素（体内系统性氧化应激的敏感指标）在房颤总体上或不同亚型房颤中均未升高。
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. There is increasing evidence that inflammation and oxidative stress contribute to the pathogenesis of AF, but their role remains poorly defined. Furthermore, it is unclear if inflammation and oxidative stress are associated with particular types of AF. The purpose of this study was to define the role of inflammation and oxidative stress in AF. Using a case-control study design, 305 patients with AF were compared to 150 control patients. AF was categorized into lone and typical AF, and further sub-categorized as paroxysmal, persistent or permanent AF. Serum concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, vascular endothelial growth factor (VEGF) and N-terminal pro-brain natriuretic peptide (NTpBNP) and urinary F2-isoprostanes, a measure of oxidative stress, were measured. IL-6, IL-8, IL-10, TNF-α, MCP1, VEGF and NTpBNP concentrations were independently associated with AF (all P values <0.05), but F2-isoprostane excretion was not elevated (P=0.50). There was a graded increase in TNF-α (median [interquartile range (IQR)]: 6.8 [3.4–11.3], 8.0 [5.6–10.9], 10.1 [5.7–12.4] pg/ml, P<0.05) and NTpBNP (170.6 [67.3–481.9], 681.39 [310.3–1439.0], 1179.9 [653.1–2096.0] pg/ml, P<0.001) among the subgroups of paroxysmal, persistent and permanent AF, respectively. This study shows that inflammatory biomarkers were significantly increased in patients with AF, supporting a strong association between inflammation and the arrhythmia. Surprisingly, urinary F2-isoprostanes, a sensitive index of systemic oxidative stress in vivo, were not increased in AF overall, or in different subtypes of AF.
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影响因子：
37.8
作者：
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通讯作者：
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DOI：
10.1111/j.1540-8159.2005.00161.x
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