Epidemiology of Thyroid Cancer.
Epidemiology of Thyroid Cancer.
复制标题
甲状腺癌的病因
DOI：
10.1158/1055-9965.epi-21-1440
复制
发表时间：
2022-07-01
期刊：
影响因子：
--
通讯作者：
Schneider AB
中科院分区：
文献类型：
--
作者：
Kitahara CM;Schneider AB
在过去的四十年里，美国甲状腺癌的发病率急剧上升，国际上观察到类似的模式。甲状腺癌目前是第13位最常见的癌症诊断，在女性中排名第6。因为在具有最高存活率的小的和局部的肿瘤中观察到发病率的最大增加，所以发病率的趋势主要归因于过度诊断，这是由于诊断成像和更灵敏的诊断工具的更广泛使用。大型和晚期甲状腺癌的发病率以及甲状腺癌死亡率的增加表明，病因因素可能导致了该病发病率的上升，尽管程度低于过度诊断。直到最近，儿童期暴露于电离辐射被认为是甲状腺癌唯一确定的可改变的风险因素。肥胖已成为另一个重要的风险因素，尽管对潜在的生物学机制仍知之甚少。内分泌干扰物和甲状腺功能障碍对甲状腺癌发展的潜在影响已成为近年来病因学研究的焦点。在确定甲状腺癌的分子亚型和遗传易感性因素方面的重要最新进展提供了关于这种疾病的病因学的见解。
BackgroundThe incidence of thyroid cancer has risen dramatically in the United States over the past four decades, with similar patterns observed internationally. Thyroid cancer currently ranks as the 13th most common cancer diagnosis overall and the 6th most common among women. Because the greatest increases in incidence have been observed for small and localized tumors having the highest rate of survival, the incidence trends have been primarily attributed to overdiagnosis, resulting from more widespread use of diagnostic imaging and more sensitive diagnostic tools. Increasing incidence of large and advanced thyroid cancers, as well as thyroid cancer mortality, suggests that etiologic factors may have contributed to rising incidence of the disease, albeit to a lesser extent than overdiagnosis. Until recently, childhood exposure to ionizing radiation was considered the only established modifiable risk factor for thyroid cancer. Obesity has emerged as another important risk factor, although the underlying biological mechanisms remain poorly understood. The potential influence of endocrine-disrupting chemicals and thyroid dysfunction on thyroid cancer development has been a focus of recent etiologic studies. Important recent advances in identifying molecular subtypes of thyroid cancer and genetic susceptibility factors provide insights regarding the etiology of this disease.
影响因子：
1.9
作者：
Dudbridge F;Brown SJ;Ward L;Wilson SG;Walsh JP
通讯作者：
Walsh JP
影响因子：
--
作者：
Chen YH;Zhang YQ
通讯作者：
Zhang YQ