Exploration of the association between FOXE1 gene polymorphism and differentiated thyroid cancer: a meta-analysis.
Exploration of the association between FOXE1 gene polymorphism and differentiated thyroid cancer: a meta-analysis.
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DOI：
10.1186/s12881-018-0604-y
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发表时间：
2018-05-22
影响因子：
--
通讯作者：
Zhang YQ
中科院分区：
文献类型：
--
作者：
Chen YH;Zhang YQ
一些关联分析和连锁研究表明，遗传变异有效地影响分化型甲状腺癌的发生。对15项已发表的分化型甲状腺癌（DTC）研究的结果进行了合并。遗传模型包括rs965513、rs944289和rs1867277。采用STATA软件进行Meta分析，采用Cochran's χ2 Q统计和I2检验评价异质性。rs965513（比值比（OR）= 1.162（1.117，1.208））、rs944289（OR = 1.082（1.035，1.131））和rs1867277（OR = 1.415（1.324，1.512））观察到显著结果。在按种族划分的亚组分析中，rs965513多态性使高加索人的风险（OR = 1.168（1.122，1.215））大于东亚人的风险（OR = 0.897（0.680，1.193））。这项荟萃分析显示，FOXE 1的常见变异（rs965513、rs944289和rs1867277）是与DTC易感性增加相关的风险因素。
Several association analyses and linkage researches indicated that inherited genetic variations effectively influence differentiated thyroid carcinogenesis. The results from 15 published studies on differentiated thyroid carcinoma (DTC) were combined. The genetic model included rs965513, rs944289 and rs1867277. Meta-analyses were performed and cochran’s χ2 based Q-statistic and I2 test were performed to assess heterogeneity using STATA software. Significant results were noticed for rs965513(Odds Ratio(OR) = 1.162(1.117, 1.208)), rs944289(OR = 1.082(1.035, 1.131)) and rs1867277(OR = 1.415(1.324, 1.512)). In the subgroup analysis by ethnicity, rs965513 polymorphism conferred that risk of Caucasians (OR = 1.168(1.122, 1.215)) was more than that of East Asians of 1.35 (OR = 0.897(0.680, 1.193)). This meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.
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影响因子：
4.5
作者：
Landa I;Ruiz-Llorente S;Montero-Conde C;Inglada-Pérez L;Schiavi F;Leskelä S;Pita G;Milne R;Maravall J;Ramos I;Andía V;Rodríguez-Poyo P;Jara-Albarrán A;Meoro A;del Peso C;Arribas L;Iglesias P;Caballero J;Serrano J;Picó A;Pomares F;Giménez G;López-Mondéjar P;Castello R;Merante-Boschin I;Pelizzo MR;Mauricio D;Opocher G;Rodríguez-Antona C;González-Neira A;Matías-Guiu X;Santisteban P;Robledo M
通讯作者：
Robledo M
影响因子：
3.7
作者：
Maillard S;Damiola F;Clero E;Pertesi M;Robinot N;Rachédi F;Boissin JL;Sebbag J;Shan L;Bost-Bezeaud F;Petitdidier P;Doyon F;Xhaard C;Rubino C;Blanché H;Drozdovitch V;Lesueur F;de Vathaire F
通讯作者：
de Vathaire F
影响因子：
3.8
作者：
Choi, Jee-Hyun;Kim, Byong-Kyu;Yoon, Sungjoo Kim
通讯作者：
Yoon, Sungjoo Kim
影响因子：
6.4
作者：
Damiola, Francesca;Byrnes, Graham;Kesminiene, Ausrele
通讯作者：
Kesminiene, Ausrele
影响因子：
6.6
作者：
Liyanarachchi, Sandya;Wojcicka, Anna;de la Chapelle, Albert
通讯作者：
de la Chapelle, Albert