Polymeric micro- and nanoparticles for immune modulation.
Polymeric micro- and nanoparticles for immune modulation.
复制标题
DOI：
10.1039/c8bm01285g
复制
发表时间：
2018-12-18
影响因子：
6.6
通讯作者：
Green JJ
中科院分区：
文献类型：
--
作者：
Ben-Akiva E ;Est Witte S ;Meyer RA ;Rhodes KR ;Green JJ
基于生物材料的调节免疫系统的方法的新进展正被应用于治疗癌症、感染性疾病和自身免疫。颗粒系统特别适合于将免疫调节因子递送至免疫细胞，因为它们的小尺寸允许它们在内化后接合细胞表面受体或在细胞内递送货物。可生物降解的聚合物颗粒是用于将信号递送至免疫系统的特别通用的平台，因为它们可以容易地表面改性以靶向特异性受体，并且被工程化以精确、持续的方式释放包封的货物。微米和纳米级系统已被用于递送各种治疗剂，包括单克隆抗体、肽和小分子药物，其用于激活免疫系统对抗癌症或传染病，或抑制免疫系统以对抗自身免疫性疾病和移植排斥。本文综述了近年来聚合物微粒和纳米颗粒系统的发展概况，这些系统用于呈递和递送针对各种免疫细胞类型（包括APC、T细胞、B细胞和NK细胞）的免疫调节剂。
New advances in biomaterial-based approaches to modulate the immune system are being applied to treat cancer, infectious diseases, and autoimmunity. Particulate systems are especially well-suited to deliver immunomodulatory factors to immune cells since their small size allows them to engage cell surface receptors or deliver cargo intracellularly after internalization. Biodegradable polymeric particles are a particularly versatile platform for the delivery of signals to the immune system because they can be easily surface-modified to target specific receptors and engineered to release encapsulated cargo in a precise, sustained manner. Micro- and nanoscale systems have been used to deliver a variety of therapeutic agents including monoclonal antibodies, peptides, and small molecule drugs that function to activate the immune system against cancer or infectious disease, or suppress the immune system to combat autoimmune diseases and transplant rejection. This review provides an overview of recent advances in the development of polymeric micro- and nanoparticulate systems for the presentation and delivery of immunomodulatory agents targeted to a variety of immune cell types including APCs, T cells, B cells, and NK cells.
登录
查看更多内容
DOI：
10.1158/1078-0432.ccr-14-2696
发表时间：
2015-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bruns H;Bessell C;Varela JC;Haupt C;Fang J;Pasemann S;Mackensen A;Oelke M;Schneck JP;Schütz C
通讯作者：
Schütz C
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
4.3
作者：
Chen, Mingshui;Ouyang, Haichao;Ye, Yunbin
通讯作者：
Ye, Yunbin
影响因子：
64.8
作者：
Clemente-Casares, Xavier;Blanco, Jesus;Santamaria, Pere
通讯作者：
Santamaria, Pere
影响因子：
14
作者：
Cho JJ;Stewart JM;Drashansky TT;Brusko MA;Zuniga AN;Lorentsen KJ;Keselowsky BG;Avram D
通讯作者：
Avram D