Improved virological and immunological efficacy of resistance-guided switch in antiretroviral therapy: a Frankfurt HIV cohort analysis.
Improved virological and immunological efficacy of resistance-guided switch in antiretroviral therapy: a Frankfurt HIV cohort analysis.
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DOI：
10.1007/s00430-014-0350-5
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发表时间：
2014-12
影响因子：
5.4
通讯作者：
Frankfurt HIV Cohort Study
中科院分区：
文献类型：
--
作者：
Wolf T;Fuß B;Khaykin P;Berger A;Knecht G;Gute P;Brodt HR;Goepel S;Bickel M;Stuermer M;Stephan C;Frankfurt HIV Cohort Study
为了评价抗逆转录病毒治疗的治疗结果，根据耐药导向转换概念的使用和效用，对来自法兰克福HIV队列的患者进行了24周的随访。如果可用，评价既往耐药数据，并将患者分组至其预期病毒应答。因此，分析了354例患者的数据，考虑了所给药物的基因型敏感性评分（>或≤ 2）。当观察达到病毒载量低于50/ml的患者比例时，具有有利耐药评分的患者的缓解率显著优于具有不利耐药评分的患者（71.9%与56.0%，p = 0.008）。有趣的是，具有有利耐药评分的患者也显示出更好的免疫应答，如通过中位CD 4细胞计数391/μl（季度间范围：250 - 530/μl）对287/μl（季度间范围：174 - 449/μl）以及141/μl对38/μl的较大总增加所测量的。一个显着的病毒学和免疫学的好处，可以证明一个队列的患者与耐药性指导抗逆转录病毒治疗的调整。
To evaluate the treatment outcome of antiretroviral therapy, depending on the use and utility of a concept of resistance-guided switch, patients from the Frankfurt HIV cohort have been followed for 24 weeks. If available, prior resistance data have been evaluated and patients were grouped into their expected viral response. The data of 354 patients were thus analyzed, taking into account the Genotypic Sensitivity Score of the administered medication (> or ≤ 2). When looking at the proportion of patients who achieved a viral load of less than 50/ml, the response rates differed significantly better for patients with a favourable resistance scoring as compared to an unfavourable one (71.9 % as compared to 56.0%, p = 0.008). Interestingly, patients with a favourable resistance score also showed a better immunological response, as measured by median CD4 cell count of 391/μl (Interquartal Range: 250 – 530/μl) against 287/μl (Interquartal Range: 174 – 449/μl) and a larger total increase of 141/μl against 38/μl. A significant virological and immunological benefit could be demonstrated for patients of a cohort with resistance-guided antiretroviral therapy adjustments.
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影响因子：
56.3
作者：
Wittkop, Linda;Guenthard, Huldrych F.;Chene, Genevieve
通讯作者：
Chene, Genevieve
影响因子：
168.9
作者：
Ledergerber, B;Lundgren, JD;Esposito, R
通讯作者：
Esposito, R
影响因子：
6.4
作者：
Le Moing, V;Thiébaut, R;Raffi, F
通讯作者：
Raffi, F
影响因子：
5.4
作者：
Stephan, Christoph;Bartha, Valentin;Bickel, Markus
通讯作者：
Bickel, Markus
DOI：
10.1056/nejmoa0803152
发表时间：
2008-10-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gulick RM;Lalezari J;Goodrich J;Clumeck N;DeJesus E;Horban A;Nadler J;Clotet B;Karlsson A;Wohlfeiler M;Montana JB;McHale M;Sullivan J;Ridgway C;Felstead S;Dunne MW;van der Ryst E;Mayer H;MOTIVATE Study Teams
通讯作者：
MOTIVATE Study Teams