Effects of white matter microstructure on phase and susceptibility maps.
Effects of white matter microstructure on phase and susceptibility maps.
复制标题
DOI：
10.1002/mrm.25189
复制
发表时间：
2015-03
影响因子：
3.3
通讯作者：
Bowtell, Richard
中科院分区：
文献类型：
--
作者：
Wharton, Samuel;Bowtell, Richard
关键词：
探讨白色物质（WM）微结构引起的频率变化对定量磁化率成像（QSM）和磁化率张量成像（STI）的影响。WM组织样本中的频率偏移，不是解释的效果，散装各向同性或各向异性的磁化率，而是从本地的微观结构的结果，其特征在于第一次。然后将QSM和STI应用于模拟频率图，这些频率图是使用从志愿者获得的解剖和扩散张量成像数据形成的数字化全脑WM模型计算的。在这个模型中，由于各向异性和微观结构的频率贡献的幅度来自组织实验的结果。模拟结果表明，微结构的频率贡献远大于各向异性磁化率的体效应。在QSM中，微观结构的贡献引入了人为的WM异质性。对于STI处理，微结构的贡献导致磁化率各向异性被显着高估。在计算的磁化率图中，WM中的微结构相关相位偏移产生伪影。如果磁化率映射是成为一个强大的MRI技术，应进行进一步的研究，以减少微结构相关的频率贡献的混杂效应。Magn Reson Med 73：1258-1269，2015.© 2014 Wiley Periodicals，Inc.
To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM). The frequency offsets in a WM tissue sample that are not explained by the effect of bulk isotropic or anisotropic magnetic susceptibility, but rather result from the local microstructure, were characterized for the first time. QSM and STI were then applied to simulated frequency maps that were calculated using a digitized whole-brain, WM model formed from anatomical and diffusion tensor imaging data acquired from a volunteer. In this model, the magnitudes of the frequency contributions due to anisotropy and microstructure were derived from the results of the tissue experiments. The simulations suggest that the frequency contribution of microstructure is much larger than that due to bulk effects of anisotropic magnetic susceptibility. In QSM, the microstructure contribution introduced artificial WM heterogeneity. For the STI processing, the microstructure contribution caused the susceptibility anisotropy to be significantly overestimated. Microstructure-related phase offsets in WM yield artifacts in the calculated susceptibility maps. If susceptibility mapping is to become a robust MRI technique, further research should be carried out to reduce the confounding effects of microstructure-related frequency contributions. Magn Reson Med 73:1258–1269, 2015. © 2014 Wiley Periodicals, Inc.
登录
查看更多内容
磁敏感性引起的白质MR信号频率转移 - 洛伦兹球体和广义洛伦兹方法之间的实验比较。
影响因子：
3.3
作者：
Luo, J.;He, X.;Yablonskiy, D. A.
通讯作者：
Yablonskiy, D. A.
DOI：
10.1016/j.jmr.2009.10.005
发表时间：
2010-01
期刊：
Journal of magnetic resonance (San Diego, Calif. : 1997)
影响因子：
--
作者：
Luo J;He X;d'Avignon DA;Ackerman JJ;Yablonskiy DA
通讯作者：
Yablonskiy DA
DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
DOI：
10.1002/cmr.b.10083
发表时间：
2003-10-01
影响因子：
0.9
作者：
Salomir, R;De Senneville, BD;Moonen, CTW
通讯作者：
Moonen, CTW
影响因子：
5.7
作者：
Sati, Pascal;van Gelderen, Peter;Silva, Afonso C.;Reich, Daniel S.;Merkle, Hellmut;de Zwart, Jacco A.;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.