Micro-compartment specific T2* relaxation in the brain.
Micro-compartment specific T2* relaxation in the brain.
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DOI：
10.1016/j.neuroimage.2013.03.005
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发表时间：
2013-08-15
期刊：
影响因子：
5.7
通讯作者：
Duyn, Jeff H.
中科院分区：
文献类型：
--
作者：
Sati, Pascal;van Gelderen, Peter;Silva, Afonso C.;Reich, Daniel S.;Merkle, Hellmut;de Zwart, Jacco A.;Duyn, Jeff H.
高场MRI可以对组织的磁特性敏感，这引入了对白色物质（WM）纤维束相对于磁场的取向的信号依赖性。此外，对该信号的NMR弛豫特性的研究表明，髓鞘内外的区室化水环境可能是可分离的。在这里，我们进一步研究了水区室化对MRI信号的影响，目的是提取区室特异性信息。通过比较人脑和绒猴脑在7T磁场模拟下的MRI测量结果，我们发现：（1）髓鞘脂质双层之间、轴突中和间隙空间中的水各自经历依赖于纤维取向的特征性磁场效应（2）这些场效应导致这些隔室的特征性弛豫特性和频率偏移;以及（3）可以通过MRI信号弛豫（即衰减）曲线的多分量拟合来分离房室贡献。我们进一步显示了这些研究结果的潜在应用，直接映射髓鞘含量和评估WM纤维的完整性与高场MRI。
MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a signal dependence on the orientation of white matter (WM) fiber bundles relative to the magnetic field. In addition, study of the NMR relaxation properties of this signal has indicated contributions from compartmentalized water environments inside and outside the myelin sheath that may be separable. Here we further investigated the effects of water compartmentalization on the MRI signal with the goal of extracting compartment-specific information. By comparing MRI measurements of human and marmoset brain at 7 T with magnetic field modeling, we show that: (1) water between the myelin lipid bilayers, in the axonal, and in the interstitial space each experience characteristic magnetic field effects that depend on fiber orientation (2) these field effects result in characteristic relaxation properties and frequency shifts for these compartments; and (3) compartmental contributions may be separated by multi-component fitting of the MRI signal relaxation (i.e. decay) curve. We further show the potential application of these findings to the direct mapping of myelin content and assessment of WM fiber integrity with high field MRI.
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DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
5.7
作者：
Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
DOI：
10.1073/pnas.0610821104
发表时间：
2007-07-10
影响因子：
11.1
作者：
Duyn, Jeff H.;van Gelderen, Peter;Fukunaga, Masaki
通讯作者：
Fukunaga, Masaki
影响因子：
3.3
作者：
Kalantari, Saeed;Laule, Cornelia;MacKay, Alex L.
通讯作者：
MacKay, Alex L.
影响因子：
4.4
作者：
Abduljalil, AM;Schmalbrock, P;Chakeres, DW
通讯作者：
Chakeres, DW