Region-specific upregulation of parvalbumin-, but not calretinin-positive cells in the ventral hippocampus during adolescence.
Region-specific upregulation of parvalbumin-, but not calretinin-positive cells in the ventral hippocampus during adolescence.
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DOI：
10.1002/hipo.22172
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发表时间：
2013-12
期刊：
影响因子：
3.5
通讯作者：
Tseng, Kuei Y.
中科院分区：
文献类型：
--
作者：
Caballero, Adriana;Diah, Kimberly C.;Tseng, Kuei Y.
动物研究强调了腹侧海马-前额叶皮质通路在青春期通过精炼GABA能回路获得成熟皮质功能中的作用。抑制性GABA能反应由高度特化的中间神经元介导，其具有独特的功能特性，并且以钙结合蛋白的表达为特征。其中，我们最近发现，小白蛋白（PV）和钙视网膜蛋白（CR）阳性的中间神经元在前额叶皮层遵循相反的发展轨迹在青春期过渡期。在本研究中，我们询问腹侧海马中表达PV和CR的中间神经元是否遵循与前额叶皮层中所见相似的青春期轨迹。通过测量三个年龄组（出生后-PD- 25-40，45-55和60-85）中这些中间神经元的相对丰度，我们发现腹侧海马背腹轴内的区域在青春期过渡期间PV表达经历了不同的发展轨迹。具体而言，腹侧下托显示PV阳性中间神经元从PD 25 -40到PD 45 -55的急剧增加，并具有增加的喙尾梯度，而在背侧和中间区域发现的变化可以忽略不计。相反，在研究的三个年龄组中，腹侧海马中CR阳性中间神经元的数量保持不变。总之，这些结果描述了第一次，GABA能电路在腹侧海马在青春期经历了长期的发展，特别是PV阳性细胞群限制到腹侧海马的腹侧区域。
Animal studies have highlighted the role of the ventral hippocampus-prefrontal cortex pathway in the acquisition of mature cortical function through refinement of GABAergic circuits during adolescence. Inhibitory GABAergic responses are mediated by highly specialized interneurons, which have distinct functional properties and are characterized by the expression of calcium binding proteins. Among these, we recently found that parvalbumin (PV)- and calretinin (CR)-positive interneurons in the prefrontal cortex follow opposite developmental trajectories during the periadolescent transition period. In the present study, we asked whether interneurons expressing PV and CR in the ventral hippocampus follow similar periadolescent trajectories as seen in the prefrontal cortex. By measuring the relative abundance of these interneurons in three age groups (postnatal days -PD- 25-40, 45-55, and 60-85), we found that regions within the dorso-ventral axis of the ventral hippocampus undergo distinct developmental trajectories in PV expression during the periadolescent transition. Specifically, the ventral subiculum displayed a dramatic increase in PV-positive interneurons from PD25-40 to PD45-55 with an increasing rostro-caudal gradient, whereas negligible changes were found in the dorsal and middle regions. In contrast, the number of CR-positive interneurons in the ventral hippocampus remained unchanged across the three age groups studied. Together, these results describe for the first time that GABAergic circuits in the ventral hippocampus undergo protracted development during adolescence, in particular the PV-positive cell population circumscribed to the ventral region of the ventral hippocampus.
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影响因子：
3.7
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通讯作者：
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