Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
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DOI：
10.1016/j.tins.2008.11.006
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发表时间：
2009-03
影响因子：
15.9
通讯作者：
Isacson, Ole
中科院分区：
文献类型：
--
作者：
Lin, Ling;Lesnick, Timothy G.;Maraganore, Demetrius M.;Isacson, Ole
轴突引导通路分子参与整个生命的连接和修复（除了在胎儿发育期间引导大脑布线）。一项研究发现，轴突导向通路基因的变异（单核苷酸多态性[SNP]）可预测全基因组关联（GWA）数据集中的三种帕金森病（PD）结局（易感性、无PD生存率和PD发病年龄）。轴突导向通路基因DCC、EPHB 1、NTNG 1、SEMA 5A和SLIT 3由预测PD结果的SNP代表。除了GWA分析，我们还提出了这些轴突导向通路分子的相关神经生物学作用，并考虑异常轴突导向分子信号传导可能导致连接丧失并最终导致PD的机制。新的药物和治疗方法可能会从这种新的理解中出现。
Axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development). One study found that variations (single-nucleotide polymorphisms [SNPs]) in axon-guidance-pathway genes were predictive of three Parkinson’s disease (PD) outcomes (susceptibility, survival free of PD and age at onset of PD) in genome-wide association (GWA) datasets. The axon-guidance-pathway genes DCC, EPHB1, NTNG1, SEMA5A and SLIT3 were represented by SNPs predicting PD outcomes. Beyond GWA analyses, we also present relevant neurobiological roles of these axon-guidance-pathway molecules and consider mechanisms by which abnormal axon-guidance-molecule signaling can cause loss of connectivity and, ultimately, PD. Novel drugs and treatments could emerge from this new understanding.
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影响因子：
5.3
作者：
Fiore, R;Rahim, B;Püschell, AW
通讯作者：
Püschell, AW
影响因子：
1.9
作者：
Johnston, MV;Blue, ME;Naidu, S
通讯作者：
Naidu, S
DOI：
10.1073/pnas.0700901104
发表时间：
2007-09-04
影响因子：
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作者：
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通讯作者：
Isacson, Ole
影响因子：
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作者：
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通讯作者：
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影响因子：
7.2
作者：
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通讯作者：
Rocca, WA