Cytotoxic capacity of a novel glycosylated antitumor ether lipid in chemotherapy-resistant high grade serous ovarian cancer in vitro and in vivo.
Cytotoxic capacity of a novel glycosylated antitumor ether lipid in chemotherapy-resistant high grade serous ovarian cancer in vitro and in vivo.
复制标题
DOI：
10.1016/j.tranon.2021.101203
复制
发表时间：
2021-11
影响因子：
5
通讯作者：
Arthur G
中科院分区：
文献类型：
--
作者：
Nachtigal MW;Musaphir P;Dhiman S;Altman AD;Schweizer F;Arthur G
L-Rham induces apoptosis-independent cell death in high grade serous ovarian cancer (HGSOC) cells. L-Rham-induced cell death is dose and time dependent in HGSOC cells grown as 2D or 3D cultures. L-Rham is as effective as paclitaxel to reduce tumor burden and metastasis in a CAM model. L-Rham significantly reduces tumor formation in a low tumor burden model. L-Rham blocks ascites formation. Chemotherapy resistant high grade serous ovarian cancer remains a clinically intractable disease with a high rate of mortality. We tested a novel glycosylated antitumor ether lipid called l-Rham to assess the in vitro and in vivo efficacy on high grade serous ovarian cancer cell lines and patient samples. l-Rham effectively kills high grade serous ovarian cancer cells grown as 2D or 3D cultures in a dose and time dependent manner. l-Rham efficacy was tested in vivo in a chicken allantoic membrane/COV362 xenograft model, where l-Rham activity was as effective as paclitaxel in reducing tumor weight and metastasis. The efficacy of l-Rham to reduce OVCAR3 tumor xenografts in NRG mice was assessed in low and high tumor burden models. l-Rham effectively reduced tumor formation in the low tumor burden group, and blocked ascites formation in low and high tumor burden animals. l-Rham demonstrates efficacy against OVCAR3 tumor and ascites formation in vivo in NRG mice, laying the foundation for further development of this drug class for the treatment of high grade serous ovarian cancer patients.
登录
查看更多内容
DOI：
10.3390/molecules181215288
发表时间：
2013-12-10
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Ogunsina M;Pan H;Samadder P;Arthur G;Schweizer F
通讯作者：
Schweizer F
影响因子：
11.2
作者：
Kuo KT;Guan B;Feng Y;Mao TL;Chen X;Jinawath N;Wang Y;Kurman RJ;Shih IeM;Wang TL
通讯作者：
Wang TL
影响因子：
4.3
作者：
McClelland, Sarah E.;Burrell, Rebecca A.;Swanton, Charles
通讯作者：
Swanton, Charles
影响因子：
4.7
作者：
Morden, Claire R.;Farrell, Ally C.;McManus, Kirk J.
通讯作者：
McManus, Kirk J.
DOI：
10.1038/nrc4019
发表时间：
2015-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Bowtell DD;Böhm S;Ahmed AA;Aspuria PJ;Bast RC Jr;Beral V;Berek JS;Birrer MJ;Blagden S;Bookman MA;Brenton JD;Chiappinelli KB;Martins FC;Coukos G;Drapkin R;Edmondson R;Fotopoulou C;Gabra H;Galon J;Gourley C;Heong V;Huntsman DG;Iwanicki M;Karlan BY;Kaye A;Lengyel E;Levine DA;Lu KH;McNeish IA;Menon U;Narod SA;Nelson BH;Nephew KP;Pharoah P;Powell DJ Jr;Ramos P;Romero IL;Scott CL;Sood AK;Stronach EA;Balkwill FR
通讯作者：
Balkwill FR