Sex Differences in Biopsy-Confirmed Diabetic Kidney Disease.
Sex Differences in Biopsy-Confirmed Diabetic Kidney Disease.
复制标题
DOI：
10.3389/fendo.2021.670674
复制
发表时间：
2021
影响因子：
5.2
通讯作者：
Liu F
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang J;Zhang J;Wu Y;Zhang R;Ren H;Cooper ME;Liu F
目的：探讨经活检证实的糖尿病肾病(DKD)患者的性别差异与终末期肾病(ESKD)的关系。我们进行了一项回溯性队列研究。总共有336名经活检证实的DKD患者接受了至少12个月的随访。收集活检时的基线临床和病理数据。ESKD的定义是估计肾小球滤过率为15ml/min/1.73m2或开始肾脏替代治疗。性别差异与ESKD之间的关联采用对数等级检验和COX回归分析。在我们的队列中有239名(71%)男性和97名(29%)女性患者。女性患者的收缩压、总胆固醇和低密度脂蛋白胆固醇水平高于男性。根据慢性肾脏疾病类别，女性患者处于极高风险级别的比例较低(女性37%，男性44%)。中位随访时间20个月，男101例(57.7%)，女43例(44.3%)进入ESKD，经对数等级检验，差异无统计学意义(P>0.05)。单变量[男性：危险比[95%可信区间]，1.005，(0.702-1.439)]和多变量[男性：危险比(95%可信区间)，1.164，(0.675-2.007)]。COX回归分析进一步显示性别差异与ESKD无显著关联。女性患者的收缩压、总胆固醇、低密度脂蛋白胆固醇高于男性患者。然而，在我们的研究中，没有观察到性别差异与ESKD之间的显著关联。
To investigate the association between sex differences and end-stage kidney disease (ESKD) in patients with biopsy-confirmed diabetic kidney disease (DKD). We performed a retrospective cohort study. A total of 336 patients with biopsy-confirmed DKD who were followed up for at least 12 months were enrolled. Baseline clinical and pathological data at the time of biopsy were collected. ESKD was defined by an estimated glomerular filtration rate of <15 ml/min/1.73 m2 or initiation of renal replacement therapy. The association between sex differences and ESKD was assessed using the log-rank test and Cox regression. There were 239 (71%) male and 97 (29%) female patients in our cohort. Female patients had higher systolic blood pressure, total cholesterol and low-density lipoprotein cholesterol levels compared with male. There were a lower proportion of female patients in the very high risk grade according to the chronic kidney disease categories (37% of female vs. 44% of male). During a median follow-up time of 20 months, 101 (57.7%) male and 43 (44.3%) female entered into ESKD, with no significant difference by the log-rank test (P >0.05). Univariate [male: hazard ratio (HR) [95% confidence interval (CI)], 1.005, (0.702–1.439)] and multivariable ([male: HR (95%CI), 1.164, (0.675–2.007)]. Cox regression further showed that sex difference was not significantly associated with ESKD. Female patients had the higher systolic blood pressure, total cholesterol, LDL-C, compared with male patients. However, there was no significant association observed between sex difference and ESKD in our study.
登录
查看更多内容
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
4.3
作者：
Kajiwara A;Kita A;Saruwatari J;Miyazaki H;Kawata Y;Morita K;Oniki K;Yoshida A;Jinnouchi H;Nakagawa K
通讯作者：
Nakagawa K
性别影响非缺血性心力衰竭的人类的心肌流动和脂肪酸底物代谢。
DOI：
10.1007/s12350-016-0467-6
发表时间：
2017-08
期刊：
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
影响因子：
--
作者：
Kadkhodayan A;Lin CH;Coggan AR;Kisrieva-Ware Z;Schechtman KB;Novak E;Joseph SM;Dávila-Román VG;Gropler RJ;Dence C;Peterson LR
通讯作者：
Peterson LR
影响因子：
120.7
作者：
Narayan, KMV;Boyle, JP;Williamson, DF
通讯作者：
Williamson, DF
影响因子：
9.3
作者：
Kautzky-Willer, Alexandra;Stich, Kathrin;Lemmens-Gruber, Rosa
通讯作者：
Lemmens-Gruber, Rosa