TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis.
TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis.
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TAK1：肝脏炎症、纤维化、脂肪变性和癌变之间的分子联系
DOI：
10.3389/fcell.2021.734749
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发表时间：
2021
影响因子：
5.5
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Wang W;Gao W;Zhu Q;Alasbahi A;Seki E;Yang L
Chronic insult and persistent injury can cause liver inflammation, fibrosis, and carcinogenesis; it can also be associated with metabolic disorders. Identification of critical molecules that link the process of inflammation and carcinogenesis will provide prospective therapeutic targets for liver diseases. Rapid advancements in gene engineering technology have allowed the elucidation of the underlying mechanism of transformation, from inflammation and metabolic disorders to carcinogenesis. Transforming growth factor-β-activated kinase 1 (TAK1) is an upstream intracellular protein kinase of nuclear factor kappa-B (NF-κB) and c-Jun N-terminal kinases, which are activated by numerous cytokines, growth factors, and microbial products. In this study, we highlighted the functional roles of TAK1 and its interaction with transforming growth factor-β, WNT, AMP-activated protein kinase, and NF-κB signaling pathways in liver inflammation, steatosis, fibrosis, and carcinogenesis based on previously published articles.
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影响因子：
12.4
作者：
Cohen P;Strickson S
通讯作者：
Strickson S
DOI：
10.1073/pnas.0404132101
发表时间：
2004-10-26
影响因子：
11.1
作者：
Ea, CK;Sun, L;Chen, ZJJ
通讯作者：
Chen, ZJJ
影响因子：
64.8
作者：
Gross, Olaf;Gewies, Andreas;Ruland, Juergen
通讯作者：
Ruland, Juergen
影响因子：
32.4
作者：
Ajibade AA;Wang Q;Cui J;Zou J;Xia X;Wang M;Tong Y;Hui W;Liu D;Su B;Wang HY;Wang RF
通讯作者：
Wang RF
影响因子：
4.8
作者：
Hamidi, Anahita;von Bulow, Verena;Landstrom, Marene
通讯作者：
Landstrom, Marene