Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla.
Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla.
复制标题
DOI：
10.1038/ncomms13133
复制
发表时间：
2016-10-31
影响因子：
16.6
通讯作者：
Oghalai, John S.
中科院分区：
文献类型：
--
作者：
Xia, Anping;Liu, Xiaofang;Raphael, Patrick D.;Applegate, Brian E.;Oghalai, John S.
大多数非哺乳动物物种的听乳头内的频率调谐是电的，来自它们的感觉毛细胞内的离子通道共振。相比之下，哺乳动物耳蜗内的调谐是机械的，源于外毛细胞内放大基底膜行波的主动机制。有趣的是，鸟类基底乳头中的毛细胞表现出电共振和力的产生，这使得人们不清楚是哪种机制产生了尖锐的频率调谐。在这里，我们测量了声音引起的振动内的顶端一半的鸡在体内的基底乳头，并发现广泛调谐行波，没有放大。然而，在活鸡而不是死鸡中发现了畸变产物。这些发现支持了鸟类毛细胞确实产生力的观点，但它们对振动的影响很小，并且不会增强调谐。因此，鸟类基底乳头顶端的频率调谐不是机械性的，很可能来自毛细胞的电共振。鸟类的听乳头与哺乳动物的耳蜗有许多相似之处，但毛细胞产生的力是否会像哺乳动物那样放大行波，仍然未知。在这里，作者表明，鸡的基底乳头没有一个“耳蜗放大器”，尖锐的频率调谐不来自机械振动。
Frequency tuning within the auditory papilla of most non-mammalian species is electrical, deriving from ion-channel resonance within their sensory hair cells. In contrast, tuning within the mammalian cochlea is mechanical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane travelling wave. Interestingly, hair cells in the avian basilar papilla demonstrate both electrical resonance and force-generation, making it unclear which mechanism creates sharp frequency tuning. Here, we measured sound-induced vibrations within the apical half of the chicken basilar papilla in vivo and found broadly-tuned travelling waves that were not amplified. However, distortion products were found in live but not dead chickens. These findings support the idea that avian hair cells do produce force, but that their effects on vibration are small and do not sharpen tuning. Therefore, frequency tuning within the apical avian basilar papilla is not mechanical, and likely derives from hair cell electrical resonance. The avian auditory papilla has many similarities to the mammalian cochlea but whether force generation by hair cells amplifies the travelling wave, as it does in mammals, remains unknown. Here the authors show that the chicken basilar papilla does not have a ‘cochlear amplifier' and that sharp frequency tuning does not derive from mechanical vibrations.
登录
查看更多内容
影响因子：
2.8
作者：
JONES, SM;JONES, TA
通讯作者：
JONES, TA
影响因子：
3.8
作者：
Gao SS;Xia A;Yuan T;Raphael PD;Shelton RL;Applegate BE;Oghalai JS
通讯作者：
Oghalai JS
影响因子：
2.4
作者：
ALLEN, JB
通讯作者：
ALLEN, JB
DOI：
10.1007/bf00603947
发表时间：
1988-01-01
影响因子：
2.1
作者：
FUCHS, PA;EVANS, MG
通讯作者：
EVANS, MG
影响因子：
2.5
作者：
Gao, Simon S.;Wang, Rosalie;Oghalai, John S.
通讯作者：
Oghalai, John S.