Maternal smoking and smokeless tobacco use during pregnancy and offspring development: sibling analysis in an intergenerational Swedish cohort.
Maternal smoking and smokeless tobacco use during pregnancy and offspring development: sibling analysis in an intergenerational Swedish cohort.
复制标题
DOI：
10.1093/ije/dyab095
复制
发表时间：
2022-01-06
影响因子：
7.7
通讯作者：
Rai D
中科院分区：
文献类型：
--
作者：
Madley-Dowd P;Lundberg M;Heron J;Zammit S;Ahlqvist VH;Magnusson C;Rai D
怀孕期间母亲吸烟与后代智力障碍（ID）之间的关系比吸烟与胎儿生长限制之间的关系更不为人所知。由于胎儿生长和认知发育可能具有相似的混淆结构，比较这两种关联可以提高对与ID关联的因果性质的理解。此外，将吸烟与无烟烟草的使用进行比较可能有助于确定作用机制。这是一项针对1999年至2012年间瑞典所有新生儿的队列研究（n = 1 070 013），具有前瞻性记录数据。我们评估了怀孕期间母亲吸烟与后代结局ID和出生时小于胎龄（SGA）之间的关系。对妊娠期鼻烟使用情况进行了重复分析。使用兄弟姐妹设计，我们估计了控制兄弟姐妹共有特征的家庭内效应。经混杂校正后，孕期暴露于母亲吸烟的孕妇患ID(比值比（OR) = 1.24, 95%可信区间（CI）： 1.16-1.33）和SGA （OR = 2.19, 95% CI: 2.11-2.27）的几率增加。SGA存在家族内效应（OR = 1.44, 95% CI: 1.27-1.63），但ID不存在家族内效应（OR = 0.92, 95% CI: 0.74-1.14）。对于鼻烟的使用，ID的结果与吸烟相似。在敏感性分析中，我们发现在怀孕期间使用鼻烟的母亲后代SGA的几率增加，但在初级分析中没有发现。我们的发现与母亲在怀孕期间吸烟对出生的SGA后代的风险有因果关系，但对ID的风险没有因果关系是一致的。我们没有发现孕期使用鼻烟对妊娠期ID有因果关系的证据，对妊娠期SGA也没有确凿的证据。
The association between maternal smoking in pregnancy and offspring intellectual disability (ID) is less well understood than that of smoking and fetal growth restriction. As fetal growth and cognitive development may share similar confounding structures, comparison of the two associations may improve understanding of the causal nature of the association with ID. Furthermore, comparisons of smoking with smokeless tobacco use may aid identification of mechanisms of action. This was a cohort study of all Swedish births between 1999 and 2012 (n = 1 070 013), with prospectively recorded data. We assessed the association between maternal smoking during pregnancy and offspring outcomes ID and born small for gestational age (SGA). Analyses were repeated for snus use in pregnancy. Using a sibling design, we estimated within-family effects that control for shared sibling characteristics. Those exposed to maternal smoking in pregnancy had increased odds of ID [odds ratio (OR) = 1.24, 95% confidence interval (CI): 1.16-1.33] and SGA (OR = 2.19, 95% CI: 2.11-2.27) after confounder adjustment. Within-family effects were found for SGA (OR = 1.44, 95% CI: 1.27-1.63) but not ID (OR = 0.92, 95% CI: 0.74-1.14). For snus use, the results for ID were similar to smoking. We found increased odds of offspring SGA among mothers who used snus in pregnancy in sensitivity analyses but not in primary analyses. Our findings are consistent with a causal effect of maternal smoking in pregnancy on risk of offspring born SGA but not on risk of ID. We found no evidence for a causal effect of snus use in pregnancy on ID and inconclusive evidence for SGA.
登录
查看更多内容
影响因子：
7.2
作者：
Madley-Dowd, Paul;Hughes, Rachael;Heron, Jon
通讯作者：
Heron, Jon
影响因子：
4.7
作者：
Baba, Sachiko;Wikstrom, Anna-Karin;Cnattingius, Sven
通讯作者：
Cnattingius, Sven
DOI：
10.1067/s0002-9378(03)00661-6
发表时间：
2003-10-01
影响因子：
9.8
作者：
England, LJ;Levine, RJ;Cnattingius, S
通讯作者：
Cnattingius, S
影响因子：
2.8
作者：
Braun, Joe M.;Daniels, Julie L.;Nicholas, Joyce S.
通讯作者：
Nicholas, Joyce S.
影响因子：
3.4
作者：
HOLM, H;JARVIS, MJ;FEYERABEND, C
通讯作者：
FEYERABEND, C