Increased Serum Interleukin-34 Levels Are Related to the Presence and Severity of Cardiac Dysfunction in Patients With Ischemic Cardiomyopathy.
Increased Serum Interleukin-34 Levels Are Related to the Presence and Severity of Cardiac Dysfunction in Patients With Ischemic Cardiomyopathy.
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血清白细胞介素 34 水平升高与缺血性心肌病患者心脏功能障碍的存在及其严重程度相关
DOI：
10.3389/fphys.2018.00904
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发表时间：
2018
影响因子：
4
通讯作者：
Tao R
中科院分区：
文献类型：
--
作者：
Xi R;Fan Q;Yan X;Zhang H;Xie H;Gu G;Xu Y;Wang F;Tao R
背景：多种炎症因子已被证明对缺血性心肌病（ICM）患者具有诊断或预后价值。白细胞介素 34 (IL-34) 是集落刺激因子 1 受体 (CSF-1R) 的另一种配体，已被确定为冠状动脉疾病 (CAD) 和慢性肾病 (CKD) 的生物标志物。然而，IL-34 在 ICM 中的潜在作用仍不清楚。方法：检测360名患有ICM的受试者和465名未患有ICM的受试者的血清IL-34水平；后者包括 233 名没有 CAD 的对照者和 232 名患有 CAD 但心功能正常的患者。进行单变量和多变量逻辑回归分析来分析IL-34和ICM之间的关系。结果：与两组未发生 ICM 的受试者相比，发生 ICM 的患者 IL-34 水平均显着升高（分别为 122.52 ± 115.30 vs. 95.02 ± 101.43 vs. 82.57 ± 84.24 pg/ml；P < 0.001）。此外，血清IL-34水平与NT-proBNP水平（r = 0.223，P < 0.001）、左心室舒张末期内径和纽约心脏协会（NYHA）功能分级呈显着正相关，表明IL-34水平越高反映心力衰竭（HF）越严重。多变量回归分析显示，在调整年龄、性别、传统危险因素以及药物治疗后，IL-34 与 ICM 的存在和严重程度显着相关[比值比 (OR)：1.501，95% 置信区间 (CI)：1.249–1.803，P < 0.001，每 SD 增加]。 IL-34 值的预测价值对于已诊断为 CAD 的患者仍然显着。结论：IL-34 水平升高与所有受试者和 CAD 患者缺血性心力衰竭的存在及其严重程度相关。 IL-34可作为具有预测价值的ICM新型临床生物标志物。
Background: Several inflammatory factors have been demonstrated with diagnostic or prognostic value in patients with ischemic cardiomyopathy (ICM). Interleukin 34 (IL-34), an additional ligand of colony stimulating factor-1 receptor (CSF-1R), has been identified as a biomarker of coronary artery disease (CAD) and chronic kidney disease (CKD). However, the potential effect of IL-34 in ICM remains unknown. Methods: Serum IL-34 levels were detected in 360 subjects with ICM and in 465 subjects without ICM; the latter group included 233 controls without CAD and 232 patients with CAD and normal cardiac function. Uni- and multivariable logistic regression analyses were conducted to analyze the relationship between IL-34 and ICM. Results: IL-34 levels were significantly increased in patients with ICM compared with both groups of subjects without ICM (122.52 ± 115.30 vs. 95.02 ± 101.43 vs. 82.57 ± 84.24 pg/ml, respectively; P < 0.001). Moreover, serum IL-34 level was significantly positively correlated to NT-proBNP level (r = 0.223, P < 0.001), left ventricular end diastolic diameter and New York Heart Association (NYHA) functional class, indicating that a higher IL-34 level reflects more severe heart failure (HF). Multivariable regression analyses revealed that IL-34 was remarkably associated with the presence and severity of ICM after adjusting for age, sex, conventional risk factors as well as medication [odds ratio (OR): 1.501, 95% confidence interval (CI): 1.249–1.803, P < 0.001, per SD increase]. The predictive value of IL-34 value remained significant in patients already diagnosed with CAD. Conclusion: Increased IL-34 levels are relevant to the presence and severity of ischemic HF in all subjects and in patients with CAD. IL-34 may be used as a novel clinical biomarker of ICM with predictive value.
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影响因子：
37.8
作者：
Robbins CS;Chudnovskiy A;Rauch PJ;Figueiredo JL;Iwamoto Y;Gorbatov R;Etzrodt M;Weber GF;Ueno T;van Rooijen N;Mulligan-Kehoe MJ;Libby P;Nahrendorf M;Pittet MJ;Weissleder R;Swirski FK
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Swirski FK
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影响因子：
5.4
作者：
Tao R;Fan Q;Zhang H;Xie H;Lu L;Gu G;Wang F;Xi R;Hu J;Chen Q;Niu W;Shen W;Zhang R;Yan X
通讯作者：
Yan X
影响因子：
1.6
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通讯作者：
Chen, Zhiqiang
影响因子：
13.5
作者：
Preisser, Laurence;Miot, Charline;Jeannin, Pascale
通讯作者：
Jeannin, Pascale
影响因子：
24
作者：
Bayes-Genis, Antoni;de Antonio, Marta;Lupon, Josep
通讯作者：
Lupon, Josep