Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders.
Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders.
复制标题
药物磁共振作为一种监测大脑药物相关效应的工具，可能为精神障碍提供潜在的生物标志物。
DOI：
10.3390/ijms22179309
复制
发表时间：
2021-08-27
影响因子：
5.6
通讯作者：
Stoyanov D
中科院分区：
文献类型：
--
作者：
Aryutova K;Stoyanov D
神经退行性和神经发育假说代表了精神分裂症起源的基本病因学框架。此外，20多年前采用的多巴胺假说，一再断言多巴胺作为一种病理生物化学底物的地位，通过精神兴奋剂和神经安定剂对中脑边缘和中皮层系统的作用，使人们深入了解阳性和阴性精神分裂症症状的起源。与此同时，精神分裂症的认知障碍仍然不完全清楚，但被认为存在于疾病的所有阶段，以及前驱期，发作间期和残留期。另一方面，观察NMDA拮抗剂，如氯胺酮和苯环己哌啶的影响，揭示了hypoamatergic神经传递不仅导致积极和消极的，但也认知精神分裂症的症状。本文旨在总结关于精神病起源的不同假设，并确定最佳的神经影像学方法，可以将它们统一在一个完整的病因学框架。我们系统地检索了Google Scholar（与发表日期无关），以确定调查精神分裂症病因的研究，重点是中枢神经传递受损。多巴胺和谷氨酸神经递质系统之间复杂的相互作用提供了长期需要的病因学概念，它结合了神经退行性疾病的假说与精神分裂症神经发育受损的假说。药物磁共振成像是一种神经影像学方法，可以将有关神经网络和不同脑区内部和之间的破坏的科学知识转化为临床适用的和有效的治疗结果，用于严重精神障碍的管理。
The neurodegenerative and neurodevelopmental hypotheses represent the basic etiological framework for the origin of schizophrenia. Additionally, the dopamine hypothesis, adopted more than two decades ago, has repeatedly asserted the position of dopamine as a pathobiochemical substrate through the action of psychostimulants and neuroleptics on the mesolimbic and mesocortical systems, giving insight into the origin of positive and negative schizophrenic symptoms. Meanwhile, cognitive impairments in schizophrenia remain incompletely understood but are thought to be present during all stages of the disease, as well as in the prodromal, interictal and residual phases. On the other hand, observations on the effects of NMDA antagonists, such as ketamine and phencyclidine, reveal that hypoglutamatergic neurotransmission causes not only positive and negative but also cognitive schizophrenic symptoms. This review aims to summarize the different hypotheses about the origin of psychoses and to identify the optimal neuroimaging method that can serve to unite them in an integral etiological framework. We systematically searched Google scholar (with no concern to the date published) to identify studies investigating the etiology of schizophrenia, with a focus on impaired central neurotransmission. The complex interaction between the dopamine and glutamate neurotransmitter systems provides the long-needed etiological concept, which combines the neurodegenerative hypothesis with the hypothesis of impaired neurodevelopment in schizophrenia. Pharmaco-magnetic resonance imaging is a neuroimaging method that can provide a translation of scientific knowledge about the neural networks and the disruptions in and between different brain regions, into clinically applicable and effective therapeutic results in the management of severe psychotic disorders.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4
作者：
Bolton, Thomas A. W.;Wotruba, Diana;Van De Ville, Dimitri
通讯作者：
Van De Ville, Dimitri
影响因子：
10.5
作者：
Cannon, Mary;Moffitt, Terrie E.;Poulton, Richie
通讯作者：
Poulton, Richie
影响因子：
6.6
作者：
Coyle, Joseph T.
通讯作者：
Coyle, Joseph T.
影响因子：
56.9
作者：
FOWLER, JS;MACGREGOR, RR;LANGSTROM, B
通讯作者：
LANGSTROM, B